Circulation, Vol 73, 662-667, Copyright © 1986 by American Heart Association
MD Winniford, KR Wheelan, MS Kremers, V Ugolini, E van den Berg Jr, EH Niggemann, DE Jansen and LD Hillis
In patients with atherosclerotic coronary artery disease, cigarette smoking
increases myocardial oxygen demand but may cause an inappropriate decrease
in coronary blood flow and myocardial oxygen supply. This study was
performed to explore the mechanism of smoking- induced coronary
vasoconstriction and, specifically, to determine if smoking causes an
alpha-adrenergically mediated increase in coronary artery tone. In 36
chronic smokers with coronary artery disease (27 men and nine women, 50 +/-
9 [mean +/- SD] years old), heart rate-systolic arterial pressure double
product and coronary sinus blood flow (by thermodilution) were measured
before and during smoking both before and after (1) normal saline (n = 5,
control subjects), (2) an alpha- adrenergic-blocking agent, phentolamine, 5
mg (n = 15), (3) a beta- adrenergic-blocking agent, propranolol, 0.1 mg/kg
(n = 12), or (4) sodium nitroprusside, 0.4 to 0.8 micrograms/kg/min, given
in a dose sufficient to diminish systolic arterial pressure by 15% (n = 4).
During the initial smoking period, rate-pressure product increased and
coronary sinus blood flow was unchanged by smoking in all groups. After 30
to 75 min, saline, phentolamine, propranolol, or sodium nitroprusside was
given, and measurements were repeated. In the control subjects,
rate-pressure product and coronary sinus blood flow responded in a similar
manner to that observed previously. In those receiving phentolamine,
rate-pressure product was unchanged, but coronary sinus blood flow rose
substantially with smoking (percent change +2 +/- 15% during the first
smoking period [before phentolamine] and +32 +/- 17% during the second
smoking period [after phentolamine]; p less than .01).(ABSTRACT TRUNCATED
AT 250 WORDS)
ARTICLES
Smoking-induced coronary vasoconstriction in patients with atherosclerotic coronary artery disease: evidence for adrenergically mediated alterations in coronary artery tone
This article has been cited by other articles:
 |
|
 |
|
  B. Lichodziejewska, K. Kurnicka, K. Grudzka, J. Malysz, M. Ciurzynski, and D. Liszewska-Pfejfer Chronic and Acute Effects of Smoking on Left and Right Ventricular Relaxation in Young Healthy Smokers Chest, April 1, 2007; 131(4): 1142 - 1148. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Najem, A. Houssiere, A. Pathak, C. Janssen, D. Lemogoum, O. Xhaet, N. Cuylits, and P. van de Borne Acute Cardiovascular and Sympathetic Effects of Nicotine Replacement Therapy Hypertension, June 1, 2006; 47(6): 1162 - 1167. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Barbato, J. Bartunek, W. Aarnoudse, M. Vanderheyden, F. Staelens, W. Wijns, G. R. Heyndrickx, N. H.J. Pijls, and B. De Bruyne Alpha-adrenergic receptor blockade and hyperaemic response in patients with intermediate coronary stenoses Eur. Heart J., November 2, 2004; 25(22): 2034 - 2039. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Barbato, J. Bartunek, E. Wyffels, W. Wijns, G. R. Heyndrickx, and B. De Bruyne Effects of intravenous dobutamineon coronary vasomotion in humans J. Am. Coll. Cardiol., November 5, 2003; 42(9): 1596 - 1601. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Neunteufl, S. Heher, K. Kostner, G. Mitulovic, S. Lehr, G. Khoschsorur, R. W. Schmid, G. Maurer, and T. Stefenelli Contribution of nicotine to acute endothelial dysfunction in long-term smokers J. Am. Coll. Cardiol., January 16, 2002; 39(2): 251 - 256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hatada, T. Sugiura, H. Kamihata, S. Nakamura, N. Takahashi, F. Yuasa, and T. Iwasaka Clinical Significance of Coronary Flow to the Infarct Zone Before Successful Primary Percutaneous Transluminal Coronary Angioplasty in Acute Myocardial Infarction Chest, December 1, 2001; 120(6): 1959 - 1963. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Lange and L. D. Hillis Cardiovascular Complications of Cocaine Use N. Engl. J. Med., August 2, 2001; 345(5): 351 - 358. [Full Text] [PDF]
|
|
|
|
 |
|
 L. Badimon, G. Vilahur, S. Sanchez, and X. Duran Atheromatous plaque formation and thrombogenesis: formation, risk factors and therapeutic approaches Eur. Heart J. Suppl., August 1, 2001; 3(suppl_I): I16 - I22. [Abstract] [PDF]
|
|
|
|
 |
|
 T.-M. Lee, S.-F. Su, W.-Y. Suo, C.-Y. Lee, M.-F. Chen, Y.-T. Lee, and C.-H. Tsai Distension of urinary bladder induces exaggerated coronary constriction in smokers with early atherosclerosis Am J Physiol Heart Circ Physiol, December 1, 2000; 279(6): H2838 - H2845. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Heusch, D. Baumgart, P. Camici, W. Chilian, L. Gregorini, O. Hess, C. Indolfi, and O. Rimoldi {alpha}-Adrenergic Coronary Vasoconstriction and Myocardial Ischemia in Humans Circulation, February 15, 2000; 101(6): 689 - 694. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Giri, P. D. Thompson, F. J. Kiernan, J. Clive, D. B. Fram, J. F. Mitchel, J. A. Hirst, R. G. McKay, and D. D. Waters Clinical and Angiographic Characteristics of Exertion-Related Acute Myocardial Infarction JAMA, November 10, 1999; 282(18): 1731 - 1736. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Markovitz, L. Tolbert, and S. E. Winders Increased Serotonin Receptor Density and Platelet GPIIb/IIIa Activation Among Smokers Arterioscler Thromb Vasc Biol, March 1, 1999; 19(3): 762 - 766. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Minami, T. Ishimitsu, and H. Matsuoka Effects of Smoking Cessation on Blood Pressure and Heart Rate Variability in Habitual Smokers Hypertension, January 1, 1999; 33(1): 586 - 590. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Jay and J. E. Hollander Cocaine Use and Chest Pain Syndromes Arch Intern Med, September 14, 1998; 158(16): 1827 - 1828. [Full Text] [PDF]
|
|
|
|
|
|
K. Narkiewicz, P. J.H. van de Borne, M. Hausberg, R. L. Cooley, M. D. Winniford, D. E. Davison, and V. K. Somers Cigarette Smoking Increases Sympathetic Outflow in Humans Circulation, August 11, 1998; 98(6): 528 - 534. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Fukuda, M. Kitani, and H. Omodani 99mTc-HMPAO Brain SPECT Imaging in a Case of Repeated Syncopal Episodes Associated With Smoking Stroke, July 1, 1997; 28(7): 1461 - 1463. [Abstract] [Full Text]
|
|
|
|
|
|
C. Stefanadis, E. Tsiamis, C. Vlachopoulos, C. Stratos, K. Toutouzas, C. Pitsavos, S. Marakas, H. Boudoulas, and P. Toutouzas Unfavorable Effect of Smoking on the Elastic Properties of the Human Aorta Circulation, January 7, 1997; 95(1): 31 - 38. [Abstract] [Full Text]
|
|
|
|
|
|
T. Heitzer, S. Yla-Herttuala, J. Luoma, S. Kurz, T. Munzel, H. Just, M. Olschewski, and H. Drexler Cigarette Smoking Potentiates Endothelial Dysfunction of Forearm Resistance Vessels in Patients With Hypercholesterolemia : Role of Oxidized LDL Circulation, April 1, 1996; 93(7): 1346 - 1353. [Abstract] [Full Text]
|
|
|
|
|
|
J. E. Hollander The Management of Cocaine-Associated Myocardial Ischemia N. Engl. J. Med., November 9, 1995; 333(19): 1267 - 1272. [Full Text] [PDF]
|
|
|
|
|
|
E. Falk, P. K. Shah, and V. Fuster Coronary Plaque Disruption Circulation, August 1, 1995; 92(3): 657 - 671. [Full Text]
|
|
|
|
 |
|
 A. D. Kugelmass and J. A. Ware Cocaine and Coronary Artery Thrombosis Ann Intern Med, May 1, 1992; 116(9): 776 - 777. [Abstract] [PDF]
|
|
|
|
|
|
R. L. Minor Jr., B. D. Scott, D. D. Brown, and M. D. Winniford Cocaine-induced Myocardial Infarction in Patients with Normal Coronary Arteries Ann Intern Med, November 15, 1991; 115(10): 797 - 806. [Abstract] [PDF]
|
|
|
|
|
|
R. A. Lange, R. G. Cigarroa, E. D. Flores, W. McBride, A. S. Kim, P. J. Wells, J. B. Bedotto, R. S. Danziger, and L. D. Hillis Potentiation of Cocaine-Induced Coronary Vasoconstriction by Beta-Adrenergic Blockade Ann Intern Med, June 15, 1990; 112(12): 897 - 903. [Abstract] [PDF]
|
|
|
|
|
|
J. Barry, K. Mead, E. G. Nabel, M. B. Rocco, S. Campbell, T. Fenton, G. H. Mudge Jr, and A. P. Selwyn Effect of Smoking on the Activity of Ischemic Heart Disease JAMA, January 20, 1989; 261(3): 398 - 402. [Abstract] [PDF]
|
|