Circulation, Vol 72, 406-412, Copyright © 1985 by American Heart Association
MA Pfeffer, JM Pfeffer, C Steinberg and P Finn
Although vasodilator therapy has been shown to improve functional capacity
in patients with congestive heart failure, there is no evidence that such
therapy can prolong survival. Coronary artery ligation in the rat was used
to produce a wide range of myocardial infarct sizes and a resultant
spectrum of left ventricular dysfunction. To determine the relationship
between size of myocardial infarction and long-term survival and to test
the hypothesis that long-term therapy with captopril could improve survival
after myocardial infarction, 302 rats were randomly assigned to either
placebo or captopril therapy 14 days after coronary artery ligation. The
animals were kept in a laminar flow unit and followed daily for a 1 year
period or until spontaneous death. Size of myocardial infarction was
determined by planimetry of serial histologic sections of the left
ventricle. One year survival in placebo-treated rats decreased markedly in
direct relation to increasing size of infarction (from 71% in noninfarcted
rats to only 8% in rats with large infarcts). Long-term captopril therapy
prolonged the survival of rats with infarcts (p less than .02). The most
marked improvement in survival was noted in the animals with infarcts of
moderate size, in which 1 year survival was 21% in the placebo-treated rats
and 48% in the captopril-treated rats. Thus, in this experimental
preparation of myocardial infarction and left ventricular dysfunction,
survival was inversely related to size of infarction. Long-term therapy
with captopril, which we had previously shown to improve left ventricular
function and lessen dilatation in the chronic phase of infarction, also had
a pronounced effect on prolonging survival in this preparation of chronic
infarction.
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J. Dupuis, J.-L. Rouleau, and P. Cernacek Reduced Pulmonary Clearance of Endothelin-1 Contributes to the Increase of Circulating Levels in Heart Failure Secondary to Myocardial Infarction Circulation, October 20, 1998; 98(16): 1684 - 1687. [Abstract] [Full Text] [PDF]
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H.J.M. G. Nelissen-Vrancken, M. C. Kuizinga, M. J.A.P. Daemen, and J. F.M. Smits Early captopril treatment inhibits DNA synthesis in endothelial cells and normalization of maximal coronary flow in infarcted rat hearts Cardiovasc Res, October 1, 1998; 40(1): 156 - 164. [Abstract] [Full Text] [PDF]
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E. Oie, R. Bjonerheim, H. K. Grogaard, H. Kongshaug, O. A. Smiseth, and H. Attramadal ET-receptor antagonism, myocardial gene expression, and ventricular remodeling during CHF in rats Am J Physiol Heart Circ Physiol, September 1, 1998; 275(3): H868 - H877. [Abstract] [Full Text] [PDF]
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H. V. Barron, A. D. Michaels, C. Maynard, N. R. Every, and for the National Registry of Myocardial Infarction Use of angiotensin-converting enzyme inhibitors at discharge in patients with acute myocardial infarction in the United States: data from the National Registry of Myocardial Infarction 2 J. Am. Coll. Cardiol., August 1, 1998; 32(2): 360 - 367. [Abstract] [Full Text] [PDF]
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K. Hu, P. Gaudron, H.-J. Anders, F. Weidemann, O. Turschner, M. Nahrendorf, and G. Ertl Chronic effects of early started angiotensin converting enzyme inhibition and angiotensin AT1-receptor subtype blockade in rats with myocardial infarction: role of bradykinin Cardiovasc Res, August 1, 1998; 39(2): 401 - 412. [Abstract] [Full Text] [PDF]
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T. Shimada, M. Yoshiyama, K. Takeuchi, T. Omura, Y. Takemoto, S. Kim, H. Iwao, and J. Yoshikawa Long acting calcium antagonist amlodipine prevents left ventricular remodeling after myocardial infarction in rats Cardiovasc Res, March 1, 1998; 37(3): 618 - 626. [Abstract] [Full Text] [PDF]
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Q. Feng, X. Lu, A. J Fortin, A. Pettersson, T. Hedner, R. L Kline, and J.M. O Arnold Elevation of an endogenous inhibitor of nitric oxide synthesis in experimental congestive heart failure Cardiovasc Res, March 1, 1998; 37(3): 667 - 675. [Abstract] [Full Text] [PDF]
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B. Ren, A. Lukas, Q. Shao, M. Guo, N. Takeda, R. M. Aitken, and N. S. Dhalla Electrocardiographic Changes and Mortality Due to Myocardial Infarction in Rats With or Without Imidapril Treatment Journal of Cardiovascular Pharmacology and Therapeutics, January 1, 1998; 3(1): 11 - 21. [Abstract] [PDF]
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D. Grimm, D. Elsner, H. Schunkert, M. Pfeifer, D. Griese, G. Bruckschlegel, F. Muders, G. A.J Riegger, and E. P Kromer Development of heart failure following isoproterenol administration in the rat: role of the renin-angiotensin system Cardiovasc Res, January 1, 1998; 37(1): 91 - 100. [Abstract] [Full Text] [PDF]
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M. St. J. Sutton, M. A. Pfeffer, L. Moye, T. Plappert, J. L. Rouleau, G. Lamas, J. Rouleau, J. O. Parker, M. O. Arnold, B. Sussex, et al. Cardiovascular Death and Left Ventricular Remodeling Two Years After Myocardial Infarction : Baseline Predictors and Impact of Long-term Use of Captopril: Information From the Survival and Ventricular Enlargement (SAVE) Trial Circulation, November 18, 1997; 96(10): 3294 - 3299. [Abstract] [Full Text]
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M. A. Pfeffer, S. C. Greaves, J. M. O. Arnold, R. J. Glynn, F. S. LaMotte, R. T. Lee, F. J. Menapace Jr, E. Rapaport, P. M. Ridker, J.-L. Rouleau, et al. Early Versus Delayed Angiotensin-Converting Enzyme Inhibition Therapy in Acute Myocardial Infarction : The Healing and Early Afterload Reducing Therapy Trial Circulation, June 17, 1997; 95(12): 2643 - 2651. [Abstract] [Full Text]
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D. Qin, Z.-H. Zhang, E. B. Caref, M. Boutjdir, P. Jain, and N. El-Sherif Cellular and Ionic Basis of Arrhythmias in Postinfarction Remodeled Ventricular Myocardium Circ. Res., September 1, 1996; 79(3): 461 - 473. [Abstract] [Full Text]
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F. Nakamura, R. D. Minshall, G. C. Le Breton, and S. F. Rabito Thromboxane A2 Mediates the Stimulation of Inositol 1,4,5-Trisphosphate Production and Intracellular Calcium Mobilization by Bradykinin in Neonatal Rat Ventricular Cardiomyocytes Hypertension, September 1, 1996; 28(3): 444 - 449. [Abstract] [Full Text]
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A. Luchner, T. L. Stevens, D. D. Borgeson, M. M. Redfield, J. E. Bailey, S. M. Sandberg, D. M. Heublein, and J. C. Burnett Angiotensin II in the Evolution of Experimental Heart Failure Hypertension, September 1, 1996; 28(3): 472 - 477. [Abstract] [Full Text]
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B. I. Jugdutt, M. J. Joljart, and M. I. Khan Rate of Collagen Deposition During Healing and Ventricular Remodeling After Myocardial Infarction in Rat and Dog Models Circulation, July 1, 1996; 94(1): 94 - 101. [Abstract] [Full Text]
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G. Melillo, J. A.C. Lima, R. M. Judd, P. J. Goldschmidt-Clermont, and H. S. Silverman Intrinsic Myocyte Dysfunction and Tyrosine Kinase Pathway Activation Underlie the Impaired Wall Thickening of Adjacent Regions During Postinfarct Left Ventricular Remodeling Circulation, April 1, 1996; 93(7): 1447 - 1458. [Abstract] [Full Text]
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R. Latini, A. P. Maggioni, M. Flather, P. Sleight, and G. Tognoni ACE Inhibitor Use in Patients With Myocardial Infarction : Summary of Evidence From Clinical Trials Circulation, November 15, 1995; 92(10): 3132 - 3137. [Full Text]
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G. M. Eaton, R. J. Cody, E. Nunziata, and P. F. Binkley Early Left Ventricular Dysfunction Elicits Activation of Sympathetic Drive and Attenuation of Parasympathetic Tone in the Paced Canine Model of Congestive Heart Failure Circulation, August 1, 1995; 92(3): 555 - 561. [Abstract] [Full Text]
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C. F. Opitz, G. F. Mitchell, M. A. Pfeffer, and J. M. Pfeffer Arrhythmias and Death After Coronary Artery Occlusion in the Rat : Continuous Telemetric ECG Monitoring in Conscious, Untethered Rats Circulation, July 15, 1995; 92(2): 253 - 261. [Abstract] [Full Text]
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S. E. Litwin, S. E. Katz, E. O. Weinberg, B. H. Lorell, G. P. Aurigemma, and P. S. Douglas Serial Echocardiographic-Doppler Assessment of Left Ventricular Geometry and Function in Rats With Pressure-Overload Hypertrophy : Chronic Angiotensin-Converting Enzyme Inhibition Attenuates the Transition to Heart Failure Circulation, May 15, 1995; 91(10): 2642 - 2654. [Abstract] [Full Text]
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K. W. Mahaffey, T. E. Raya, G. D. Pennock, E. Morkin, and S. Goldman Left Ventricular Performance and Remodeling in Rabbits After Myocardial Infarction : Effects of a Thyroid Hormone Analogue Circulation, February 1, 1995; 91(3): 794 - 801. [Abstract] [Full Text]
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