Circulation, Vol 72, 183-192, Copyright © 1985 by American Heart Association
SA Wickline, LJ Thomas 3d, JG Miller, BE Sobel and JE Perez
We have recently shown that the cardiac cycle-dependent variation in
myocardial ultrasonic integrated backscatter is blunted with regional
ischemia in dogs. To determine if global and intramural regional myocardial
contractile performance can be quantified by integrated backscatter, we
analyzed ultrasonic responses after induction of increased and decreased
contractility in five dogs. A recently developed analog data-acquisition
system for measuring integrated backscatter in real time was used to sample
radiofrequency signals gated from subepicardial or subendocardial regions.
Base-line recordings of integrated backscatter, left ventricular pressure,
left ventricular dP/dt, and wall thickness were made at 12 left ventricular
sites for both intramural regions. Contractility was modified subsequently
by either paired pacing or propranolol to produce significantly elevated or
depressed values for maximum left ventricular dP/dt compared with baseline
(1083 +/- 289 to 3001 +/- 570 mm Hg/sec; p less than .01 for all). The
amplitude of the cyclic variation of integrated backscatter was 50% greater
(arithmetically) in subendocardial than in subepicardial regions for all
treatments (7.6 +/- 0.3 vs 6.0 +/- 0.5 dB, p less than .001). The maximum
rate of change in integrated backscatter waveforms during isovolumetric
contraction was faster with paired pacing and slower with propranolol than
at baseline for all regions (56 +/- 6 to 74 +/- 6 to 82 +/- 5 dB/sec, p
less than .005). The maximum rate of change in integrated backscatter also
was greater in subendocardial than subepicardial regions (p less than
.001). Thus, both regional and global differences in myocardial contractile
performance are manifest quantitatively in integrated backscatter
waveforms. We propose that the physiologic determinants of these
differences may depend on regional and global variations in myofibril
elastic characteristics.
ARTICLES
The dependence of myocardial ultrasonic integrated backscatter on contractile performance
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