Circulation, Vol 71, 1029-1037, Copyright © 1985 by American Heart Association
GR Heyndrickx, J Amano, TA Patrick, WT Manders, GG Rogers, C Rosendorff and SF Vatner
The effects of coronary artery reperfusion initiated 1 hr and 3 hr after
coronary artery occlusion were evaluated on measurements of overall and
regional left ventricular function and on regional myocardial blood flow.
These experiments were conducted in conscious baboons 2 to 3 weeks after
recovery from instrumentation with a solid state left ventricular pressure
gauge, aortic and left atrial catheters, a hydraulic occluder around the
mid left anterior descending coronary artery, and pairs of ultrasonic
transducers implanted in the endocardium of the left ventricular free wall
or across the free wall to measure endocardial segment shortening and wall
thickening, respectively. Coronary artery occlusion induced similar effects
in both groups. At 1 hr after occlusion, the ischemic zone was
characterized by severe and equal reductions in both endocardial (-97 +/-
1%) and epicardial (-95 +/- 4%) blood flows and complete loss of regional
systolic function, which was replaced by paradoxical wall motion.
Reperfusion initiated after 1 hr of ischemia was associated with a marked
transient increase in endocardial (+386 +/- 51%) and epicardial (+544 +/-
79%) blood flows. During the subsequent 4 weeks, segment shortening and
wall thickening tended to improve. However, at 4 weeks after reperfusion,
segment shortening was still depressed by 45 +/- 12% and wall thickening by
58 +/- 14%. In contrast, reperfusion initiated after 3 hr of ischemia was
not associated with a significant hyperemic response, and systolic segment
shortening and wall thickening did not recover during the subsequent 4 week
period.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Effects of coronary artery reperfusion on regional myocardial blood flow and function in conscious baboons
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