Circulation, Vol 71, 709-716, Copyright © 1985 by American Heart Association
K Kohchi, S Takebayashi, T Hiroki and M Nobuyoshi
A quantitative analysis of adventitial inflammation of the coronary artery
with intimal lesions is described in 12 patients who suffered coronary
death and had had unstable angina (crescendo angina) at rest (group 1).
After autopsy in these patients we examined epon-embedded cross sections by
light and electron microscopy, paying particular attention to the
adventitia, and compared these results with those in six patients who had
had angina but died of noncardiac causes (group 2) and those in 22 patients
who did not have angina (group 3). Of the 132 segments from group 1
patients, 39 (30%) were narrowed 76% to 100% by atherosclerotic plaque
(group 2, 27%; group 3, 1%), and 23 (17%) had occlusive thrombi. Of the 264
sections (two from each segment) from group 1 that were examined, 98 (37%)
(group 2, 15%; group 3, 9%) revealed clustered infiltration of inflammatory
cells in the adventitia, half of which were associated with vascular nerve
involvement. These findings in the adventitia may be related to the
vasospastic component of unstable angina.
ARTICLES
Significance of adventitial inflammation of the coronary artery in patients with unstable angina: results at autopsy
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