Circulation, Vol 71, 90-97, Copyright © 1985 by American Heart Association
MJ Cowley, SM Mullin, SF Kelsey, KM Kent, AR Gruentzig, KM Detre and ER Passamani
To assess whether gender influenced the outcome of percutaneous
transluminal coronary angioplasty (PTCA), we analyzed data from the NHLBI
PTCA Registry. Early results were compared in 705 women and 2374 men. Women
were older (p less than .01) and had more unstable angina (p less than
.01), and class 3 or 4 angina (p less than .01). Men had more multivessel
disease (p less than .01), prior bypass surgery (p less than .01), and
abnormal left ventricular function (p less than .05). Women had a lower
angiographic success rate (60.3 vs 66.2%; p less than .01) and had a lower
clinical success rate (56.6% vs 62.2%; p less than .01). More women had
complications (27.2% vs 19.4%; p less than .01), but overall frequency of
major complications (death, myocardial infarction, emergency surgery) was
not different (9.8% vs 9.3%). Women had a higher incidence of coronary
dissection (p less than .05) and higher in-hospital mortality (1.8% vs
0.7%; p less than .01). PTCA- related mortality was nearly six times higher
in women (1.7% vs 0.3%; p less than .001) and mortality with emergency
surgery was more than five time higher (17.4% vs 3.2%; p less than .001).
Multivariate analysis indicated that female gender was an independent
predictor for lower success (p less than .05) and early mortality (p less
than .05) and was the only baseline predictor for PTCA-related
mortality.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Sex differences in early and long-term results of coronary angioplasty in the NHLBI PTCA Registry
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