Circulation, Vol 69, 1065-1069, Copyright © 1984 by American Heart Association
E Barrett-Connor and K Khaw
Although a family history of ischemic heart disease is a well-accepted risk
factor for cardiovascular disease, only three prospective studies-- all in
men--have examined the predictive strength of a positive family history
after adjusting for other heart disease risk factors. The present analysis
is based on a 9 year follow-up of 4014 men and women from 40 to 79 years
old who resided in Rancho Bernardo, CA, and who reported no known
cardiovascular disease in response to a standardized interview. At baseline
38% of this group reported a family history of a heart attack in a parent,
sibling, or child; 15% of those with a positive family history in a
first-degree relative indicated that the heart attack had occurred before
the relative was 50 years old. Younger men (less than 60 years) with a
positive family history at any age had significantly higher mean blood
pressures and total plasma cholesterol levels; older men were more likely
to have diabetes mellitus. Younger women with a positive family heart
attack to subsequent cardiovascular death was determined by the Cox model
after adjusting for age, systolic blood pressure, total plasma cholesterol
level, obesity, cigarette smoking, personal history of diabetes, and
estrogen use (in women). In men, but not in women, a positive family
history of heart attack was independently predictive of death from all
causes and from cardiovascular and ischemic heart disease.(ABSTRACT
TRUNCATED AT 250 WORDS)
ARTICLES
Family history of heart attack as an independent predictor of death due to cardiovascular disease
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