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Circulation, Vol 69, 250-258, Copyright © 1984 by American Heart Association
JT Bigger Jr, JL Fleiss, R Kleiger, JP Miller and LM Rolnitzky
We examined the relationships among ventricular arrhythmias, left
ventricular dysfunction, and mortality after the occurrence of myocardial
infarction in 766 patients who enrolled in a nine-hospital study and
underwent two special tests. Frequency and repetitiveness of ventricular
premature depolarizations (VPDs) were determined by computer analysis of
predischarge 24 hr electrocardiographic recordings. The left ventricular
ejection fraction (LVEF) was determined by radionuclide ventriculography
and dichotomized at its optimal value of 30%. Frequency of VPDs was divided
into three categories: (1) less than one per hour, (2) one to 2.9 per hour,
and (3) three or more per hour. Repetitiveness of VPDs was also divided
into three categories: (1) no repetitive VPDs, (2) paired VPDs, and (3) VPD
runs. These variables were related, one at a time and jointly, to total
mortality and to deaths caused by arrhythmias. The hazard ratios for dying
in the higher or highest risk stratum vs the lower or lowest stratum for
each variable (adjusted for the effects of the others) were: LVEF below
30%, 3.5; VPD runs, 1.9; and VPD frequency of three or more per hour, 2.0.
There were no significant interactions among the three variables with
respect to effects on the risk of mortality. There was a suggestion of an
interaction between each risk variable and time after infarction. LVEF
below 30% was a better predictor of early mortality (less than 6 months)
and the presence of ventricular arrhythmias was a better predictor of late
mortality (after 6 months).(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
The relationships among ventricular arrhythmias, left ventricular dysfunction, and mortality in the 2 years after myocardial infarction
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B. Waldecker, W. Waas, W. Haberbosch, R. Voss, H. Heizmann, and H. Tillmanns Long-term follow-up after direct percutaneous transluminal coronary angioplasty for acute myocardial infarction J. Am. Coll. Cardiol., November 1, 1998; 32(5): 1320 - 1325. [Abstract] [Full Text] [PDF]
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J. Meluzin, J. Cerny, M. Frelich, F. Stetka, L. Spinarova, J. Popelova, R. Stipal, and on behalf of the Investigators of This Multicenter Prognostic value of the amount of dysfunctional but viable myocardium in revascularized patients with coronary artery disease and left ventricular dysfunction J. Am. Coll. Cardiol., October 1, 1998; 32(4): 912 - 920. [Abstract] [Full Text] [PDF]
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S. N. Singh, S. G. Fisher, P. E. Carson, R. D. Fletcher, and the Department of Veterans Affairs CHF STAT Invest Prevalence and significance of nonsustained ventricular tachycardia in patients with premature ventricular contractions and heart failure treated with vasodilator therapy J. Am. Coll. Cardiol., October 1, 1998; 32(4): 942 - 947. [Abstract] [Full Text] [PDF]
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S R Redwood, R Ferrari, and M S Marber Myocardial hibernation and stunning: from physiological principles to clinical practice Heart, September 1, 1998; 80(3): 218 - 222. [Full Text]
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R. G. Favaloro Landmarks in the Development of Coronary Artery Bypass Surgery Circulation, August 4, 1998; 98(5): 466 - 478. [Full Text] [PDF]
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M. Zabel, T. Klingenheben, M. R. Franz, and S. H. Hohnloser Assessment of QT Dispersion for Prediction of Mortality or Arrhythmic Events After Myocardial Infarction : Results of a Prospective, Long-term Follow-up Study Circulation, June 30, 1998; 97(25): 2543 - 2550. [Abstract] [Full Text] [PDF]
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S. Ozgul and G. Z. Kudaiberdieva Silent Myocardial Ischemia After Myocardial Infarction: Severity of Coronary Artery Disease, Impact on Left Ventricular Systolic and Diastolic Functions and Prognosis Angiology, June 1, 1998; 49(6): 455 - 462. [Abstract] [PDF]
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R. J. Myerburg, R. Mitrani, A. Interian Jr, and A. Castellanos Interpretation of Outcomes of Antiarrhythmic Clinical Trials : Design Features and Population Impact Circulation, April 21, 1998; 97(15): 1514 - 1521. [Full Text] [PDF]
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K Siogas, S Pappas, G Graekas, J Goudevenos, G Liapi, and D A Sideris Segmental wall motion abnormalities alter vulnerability to ventricular ectopic beats associated with acute increases in aortic pressure in patients with underlying coronary artery disease Heart, March 1, 1998; 79(3): 268 - 273. [Abstract] [Full Text]
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J. T. Bigger and The Coronary Artery Bypass Graft (CABG) Patch Tria Prophylactic Use of Implanted Cardiac Defibrillators in Patients at High Risk for Ventricular Arrhythmias after Coronary-Artery Bypass Graft Surgery N. Engl. J. Med., November 27, 1997; 337(22): 1569 - 1575. [Abstract] [Full Text] [PDF]
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I. Sim, K. M. McDonald, P. W. Lavori, C. M. Norbutas, and M. A. Hlatky Quantitative Overview of Randomized Trials of Amiodarone to Prevent Sudden Cardiac Death Circulation, November 4, 1997; 96(9): 2823 - 2829. [Abstract] [Full Text]
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G. E. Billman, L. C. Castillo, J. Hensley, C. M. Hohl, and R. A. Altschuld ß2-Adrenergic Receptor Antagonists Protect Against Ventricular Fibrillation : In Vivo and In Vitro Evidence for Enhanced Sensitivity to ß2-Adrenergic Stimulation in Animals Susceptible to Sudden Death Circulation, September 16, 1997; 96(6): 1914 - 1922. [Abstract] [Full Text]
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M. J. Domanski, D. P. Zipes, and E. Schron Treatment of Sudden Cardiac Death : Current Understandings From Randomized Trials and Future Research Directions Circulation, June 17, 1997; 95(12): 2694 - 2699. [Full Text]
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P. Lander, P. Gomis, R. Goyal, E. J. Berbari, P. Caminal, R. Lazzara, and J. S. Steinberg Analysis of Abnormal Intra-QRS Potentials : Improved Predictive Value for Arrhythmic Events With the Signal-Averaged Electrocardiogram Circulation, March 18, 1997; 95(6): 1386 - 1393. [Abstract] [Full Text]
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P. C. Deedwania, E. A. Amsterdam, and R. H. Vagelos Evidence-Based, Cost-effective Risk Stratification and Management After Myocardial Infarction Arch Intern Med, February 10, 1997; 157(3): 273 - 280. [Abstract] [PDF]
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A. J. Moss, W. J. Hall, D. S. Cannom, J. P. Daubert, S. L. Higgins, H. Klein, J. H. Levine, S. Saksena, A. L. Waldo, D. Wilber, et al. Improved Survival with an Implanted Defibrillator in Patients with Coronary Disease at High Risk for Ventricular Arrhythmia N. Engl. J. Med., December 26, 1996; 335(26): 1933 - 1940. [Abstract] [Full Text] [PDF]
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E. A. Halm, W. S. Browner, J. F. Tubau, I. M. Tateo, and D. T. Mangano Echocardiography for Assessing Cardiac Risk in Patients Having Noncardiac Surgery Ann Intern Med, September 15, 1996; 125(6): 433 - 441. [Abstract] [Full Text]
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A. E. Buxton, K. L. Lee, L. DiCarlo, D. S. Echt, J. D. Fisher, G. S. Greer, M. E. Josephson, D. Packer, E. N. Prystowsky, M. Talajic, et al. Nonsustained Ventricular Tachycardia in Coronary Artery Disease: Relation to Inducible Sustained Ventricular Tachycardia Ann Intern Med, July 1, 1996; 125(1): 35 - 39. [Abstract] [Full Text]
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J. T. Bigger Jr, R. C. Steinman, L. M. Rolnitzky, J. L. Fleiss, P. Albrecht, and R. J. Cohen Power Law Behavior of RR-Interval Variability in Healthy Middle-Aged Persons, Patients With Recent Acute Myocardial Infarction, and Patients With Heart Transplants Circulation, June 15, 1996; 93(12): 2142 - 2151. [Abstract] [Full Text]
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J. A. Reiffel Data-driven Decisions: The Importance of Clinical Trials in Arrhythmia Management Journal of Cardiovascular Pharmacology and Therapeutics, January 1, 1996; 1(1): 79 - 88. [Abstract] [PDF]
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M. O. Sweeney, J. N. Ruskin, H. Garan, B. A. McGovern, M. L. Guy, D. F. Torchiana, G. J. Vlahakes, J. B. Newell, M. J. Semigran, and G. W. Dec Influence of the Implantable Cardioverter/Defibrillator on Sudden Death and Total Mortality in Patients Evaluated for Cardiac Transplantation Circulation, December 1, 1995; 92(11): 3273 - 3281. [Abstract] [Full Text]
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A. Farb, A. L. Tang, A. P. Burke, L. Sessums, Y. Liang, and R. Virmani Sudden Coronary Death : Frequency of Active Coronary Lesions, Inactive Coronary Lesions, and Myocardial Infarction Circulation, October 1, 1995; 92(7): 1701 - 1709. [Abstract] [Full Text]
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C. L. Hubley-Kozey, L. B. Mitchell, M. J. Gardner, J. W. Warren, C. J. Penney, E. R. Smith, and B. M. Horacek Spatial Features in Body-Surface Potential Maps Can Identify Patients With a History of Sustained Ventricular Tachycardia Circulation, October 1, 1995; 92(7): 1825 - 1838. [Abstract] [Full Text]
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F. Avanzini, R. Latini, A. Maggioni, F. Colombo, E. Santoro, M. G. Franzosi, G. Tognoni, and GISSI Investigators Antiarrhythmic Drug Prescription in Patients After Myocardial Infarction in the Last Decade: Experience of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico (GISSI) Arch Intern Med, May 22, 1995; 155(10): 1041 - 1045. [Abstract] [PDF]
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A. R. R. Misier, T. Opthof, N. M. van Hemel, J. T. Vermeulen, J. M.T. de Bakker, J. J.A.M. Defauw, F. J.L. van Capelle, and M. J. Janse Dispersion of `Refractoriness' in Noninfarcted Myocardium of Patients With Ventricular Tachycardia or Ventricular Fibrillation After Myocardial Infarction Circulation, May 15, 1995; 91(10): 2566 - 2572. [Abstract] [Full Text]
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