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Circulation, Vol 67, 1016-1023, Copyright © 1983 by American Heart Association
JL Romson, BG Hook, SL Kunkel, GD Abrams, MA Schork and BR Lucchesi
Accumulation of polymorphonuclear neutrophils during the acute inflammatory
response may exacerbate tissue injury through the release of activated
oxygen products or proteolytic enzymes or both. To assess the role of
neutrophils in acute myocardial infarction, circulating neutrophil levels
in dogs were reduced by 77 +/- 2% (mean +/- SEM) by administering rabbit
antiserum to dog neutrophils. Acute myocardial infarction was induced in
open-chest anesthetized dogs by 90 minutes of left circumflex coronary
artery occlusion followed by 6 hours of reperfusion. Dogs treated with
neutrophil antiserum (n = 8) developed myocardial infarcts that were an
average of 43% smaller than infarcts in dogs treated with nonimmune rabbit
serum (n = 7) (27.0 +/- 4.5% vs 47.1% +/- 7.5% of the area at risk, p less
than 0.05). In a saline- treated control group (n = 8), infarct size was
48.0 +/- 4.7% of the area at risk, a value not significantly different from
that of the nonimmune serum group but significantly greater than that in
the neutrophil antiserum dogs (p less than 0.05). There were no major
hemodynamic differences between groups. Histopathologic examination
revealed that infarcted myocardium from dogs given saline or treated with
nonimmune serum had a substantial neutrophilic infiltrate, which was
virtually absent in infarcted tissue from dogs treated with neutrophil
antiserum. These observations suggest that neutrophil accumulation in
response to myocardial ischemia may be responsible for a substantial
portion of the irreversible myocardial injury resulting from temporary
coronary artery occlusion.
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H. Yaoita, K. Ogawa, K. Maehara, and Y. Maruyama Attenuation of Ischemia/Reperfusion Injury in Rats by a Caspase Inhibitor Circulation, January 27, 1998; 97(3): 276 - 281. [Abstract] [Full Text] [PDF]
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K. S. Kilgore, E. J. Tanhehco, J. L. Park, K. B. Naylor, M. B. Anderson, and B. R. Lucchesi Reduction of Myocardial Infarct Size In Vivo by Carbohydrate-Based Glycomimetics J. Pharmacol. Exp. Ther., January 1, 1998; 284(1): 427 - 435. [Abstract] [Full Text]
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P. F. Pratt, J. R. Falck, K. M. Reddy, J. B. Kurian, and W. B. Campbell 20-HETE Relaxes Bovine Coronary Arteries Through the Release of Prostacyclin Hypertension, January 1, 1998; 31(1): 237 - 241. [Abstract] [Full Text] [PDF]
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R. Hayward, T. O. Nossuli, and A. M. Lefer Heparinase III Exerts Endothelial and Cardioprotective Effects in Feline Myocardial Ischemia-Reperfusion Injury J. Pharmacol. Exp. Ther., December 1, 1997; 283(3): 1032 - 1038. [Abstract] [Full Text]
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L. Ostrovsky, R. C. Woodman, D. Payne, D. Teoh, and P. Kubes Antithrombin III Prevents and Rapidly Reverses Leukocyte Recruitment in Ischemia/Reperfusion Circulation, October 7, 1997; 96(7): 2302 - 2310. [Abstract] [Full Text]
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H. Sato, J. E. Jordan, Z.-Q. Zhao, S. S. Sarvotham, and J. Vinten-Johansen Gradual Reperfusion Reduces Infarct Size and Endothelial Injury but Augments Neutrophil Accumulation Ann. Thorac. Surg., October 1, 1997; 64(4): 1099 - 1107. [Abstract] [Full Text]
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P. H. Reinhardt, C. A. Ward, W. R. Giles, and P. Kubes Emigrated Rat Neutrophils Adhere to Cardiac Myocytes via {alpha}4 Integrin Circ. Res., August 19, 1997; 81(2): 196 - 201. [Abstract] [Full Text]
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T. Asanuma, K. Tanabe, K. Ochiai, H. Yoshitomi, K. Nakamura, Y. Murakami, K. Sano, T. Shimada, R. Murakami, S. Morioka, et al. Relationship Between Progressive Microvascular Damage and Intramyocardial Hemorrhage in Patients With Reperfused Anterior Myocardial Infarction : Myocardial Contrast Echocardiographic Study Circulation, July 15, 1997; 96(2): 448 - 453. [Abstract] [Full Text]
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J. E. Jordan, Z.-Q. Zhao, H. Sato, S. Taft, and J. Vinten-Johansen Adenosine A2 Receptor Activation Attenuates Reperfusion Injury by Inhibiting Neutrophil Accumulation, Superoxide Generation and Coronary Endothelial Adherence J. Pharmacol. Exp. Ther., January 1, 1997; 280(1): 301 - 309. [Abstract] [Full Text]
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R. J. Gumina, J. E. Schultz, Z. Yao, D. Kenny, D. C. Warltier, P. J. Newman, and G. J. Gross Antibody to Platelet/Endothelial Cell Adhesion Molecule-1 Reduces Myocardial Infarct Size in a Rat Model of Ischemia-Reperfusion Injury Circulation, December 15, 1996; 94(12): 3327 - 3333. [Abstract] [Full Text]
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B. Takase, T. Maruyama, A. Kurita, A. Uehata, T. Nishioka, K. Mizuno, H. Nakamura, K. Katsura, and Y. Kanda Arachidonic Acid Metabolites in Acute Myocardial Infarction Angiology, July 1, 1996; 47(7): 649 - 661. [Abstract] [PDF]
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 H. Nishiwaki, Y. Ogura, K. Miyamoto, N. Matsuda, and Y. Honda Interferon Alfa Induces Leukocyte Capillary Trapping in Rat Retinal Microcirculation Arch Ophthalmol, June 1, 1996; 114(6): 726 - 730. [Abstract] [PDF]
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F. M. Sheridan, P. G. Cole, and D. Ramage Leukocyte Adhesion to the Coronary Microvasculature During Ischemia and Reperfusion in an In Vivo Canine Model Circulation, May 15, 1996; 93(10): 1784 - 1787. [Abstract] [Full Text]
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D. Hasdai, N. Varda-Bloom, N. Blumberg, D. Ohad, R. Kornowski, and A. Battler The Effect of Low Molecular Weight Heparin (Fragmin) on Myocardial Neutrophil Accumulation and Infarct Size in a Rat Model of Myocardial Infarction Angiology, May 1, 1996; 47(5): 491 - 499. [Abstract] [PDF]
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S. Allen Leucocyte depletion in cardiothoracic surgery Perfusion, May 1, 1996; 11(3): 270 - 277. [PDF]
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Y. Sawa, K. Taniguchi, K. Kadoba, M. Nishimura, H. Ichikawa, A. Amemiya, T. Kuratani, and H. Matsuda Leukocyte Depletion Attenuates Reperfusion Injury in Patients With Left Ventricular Hypertrophy Circulation, May 1, 1996; 93(9): 1640 - 1646. [Abstract] [Full Text]
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 K. S. Kilgore, J. L. Park, L. Chi, J. H. Musser, V. Date, S. Abbas, and B. R. Lucchesi Reduction of Myocardial Infarct Size in the Rabbit by a Carbohydrate Analog of Sialyl Lewisx Journal of Cardiovascular Pharmacology and Therapeutics, January 1, 1996; 1(1): 49 - 56. [Abstract] [PDF]
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S. A. Burns, J. W. Newburger, M. Xiao, J. E. Mayer Jr, A. Z. Walsh BSN, and E. J. Neufeld Induction of Interleukin-8 Messenger RNA in Heart and Skeletal Muscle During Pediatric Cardiopulmonary Bypass Circulation, November 1, 1995; 92(9): 315 - 321. [Abstract] [Full Text]
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M. C. Oz, H. Liao, Y. Naka, A. Seldomridge, D. N. Becker, R. E. Michler, C. R. Smith, E. A. Rose, D. M. Stern, and D. J. Pinsky Ischemia-Induced Interleukin-8 Release After Human Heart Transplantation : A Potential Role for Endothelial Cells Circulation, November 1, 1995; 92(9): 428 - 432. [Abstract] [Full Text]
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G. Wernovsky, D. Wypij, R. A. Jonas, J. E. Mayer Jr, F. L. Hanley, P. R. Hickey, A. Z. Walsh, A. C. Chang, A. R. Castaneda, J. W. Newburger, et al. Postoperative Course and Hemodynamic Profile After the Arterial Switch Operation in Neonates and Infants : A Comparison of Low-Flow Cardiopulmonary Bypass and Circulatory Arrest Circulation, October 15, 1995; 92(8): 2226 - 2235. [Abstract] [Full Text]
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M. J. Silver, J. M. Sutton, S. Hook, P. Lee, J. L. Malycky, M. L. Phillips, S. G. Ellis, E. J. Topol, and F. A. Nicolini Adjunctive Selectin Blockade Successfully Reduces Infarct Size Beyond Thrombolysis in the Electrolytic Canine Coronary Artery Model Circulation, August 1, 1995; 92(3): 492 - 499. [Abstract] [Full Text]
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P. R. Hansen Role of Neutrophils in Myocardial Ischemia and Reperfusion Circulation, March 15, 1995; 91(6): 1872 - 1885. [Abstract] [Full Text]
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M. Buerke, T. Murohara, and A. M. Lefer Cardioprotective Effects of a C1 Esterase Inhibitor in Myocardial Ischemia and Reperfusion Circulation, January 15, 1995; 91(2): 393 - 402. [Abstract] [Full Text]
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L. Andersen, J. Thiis, A. Kharazmi, and I. Rygg The role of N-acetylcystein administration on the oxidative response of neutrophils during cardiopulmonary bypass Perfusion, January 1, 1995; 10(1): 21 - 26. [Abstract] [PDF]
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P. M. Kilbridge, J. E. Mayer, J. W. Newburger, P. R. Hickey, A. Z. Walsh, and E. J. Neufeld Induction of intercellular adhesion molecule-1 and E-selectin mRNA in heart and skeletal muscle of pediatric patients undergoing cardiopulmonary bypass J. Thorac. Cardiovasc. Surg., May 1, 1994; 107(5): 1183 - 1192. [Abstract] [Full Text]
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R. Kapoor, J. Kalra, and K. Prasad Beneficial Effects of Methionine on Myocardial Hemodynamic and Cellular Functions in Hemorrhagic Shock Angiology, April 1, 1992; 43(4): 294 - 305. [Abstract] [PDF]
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A. A. Rodriguez, W. W. LaMorte, L. M. Hanrahan, S. R. Hopkins, J. C. O'Keane, R. Cachecho, and E. F. Hirsch Liver Viability After Ischemia-Reperfusion Arch Surg, June 1, 1991; 126(6): 767 - 772. [Abstract] [PDF]
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 J. M. Hallenbeck and A. J. Dutka Background Review and Current Concepts of Reperfusion Injury Arch Neurol, November 1, 1990; 47(11): 1245 - 1254. [Abstract] [PDF]
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