Circulation, Vol 66, 355-360, Copyright © 1982 by American Heart Association
A Matsumori and C Kawai
To investigate whether lesions that develop in the chronic stage of viral
myocarditis are similar to those seen in congestive (dilated)
cardiomyopathy, we studied myocarditis in inbred strains of DBA/2 mice
infected with encephalomyocarditis (EMC) virus. Myocardial necrosis with
calcification appeared on day 4. Thereafter, myocardial necrosis became
more extensive and mononuclear cell infiltration was evident and was most
marked on day 14. On day 90, cellular infiltration had decreased and
myocardial fibrosis was prominent. At this stage, the heart weight was
significantly greater in the infected mice than in the controls (0.190 +/-
0.028 g vs 0.122 +/- 0.013 g, mean +/- SD) (p less than 0.001) and the
cavity dimensions of the left ventricle were larger (1.67 +/- 0.29 mm vs
1.11 +/- 0.20 mm) (p less than 0.001). The diameters of myocardial fibers
of the right ventricle, the interventricular septum and the left ventricle
were significantly larger than those of the controls (right ventricle, 16.6
+/- 1.8 vs 13.4 +/- 1.5 micrometer; interventricular septum, 17.8 +/- 1.5
vs 13.8 +/- 1.5 micrometer; left ventricle, 19.4 +/- 1.7 vs 14.8 +/- 1.1
micrometer) (p less than 0.001). This study demonstrates that in viral
myocarditis in the chronic stage, lesions develop that resemble those seen
in congestive cardiomyopathy.
ARTICLES
An animal model of congestive (dilated) cardiomyopathy: dilatation and hypertrophy of the heart in the chronic stage in DBA/2 mice with myocarditis caused by encephalomyocarditis virus
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