This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lindenfeld, J. Articles by Horwitz, L. D. Search for Related Content PubMed PubMed Citation Articles by Lindenfeld, J. Articles by Horwitz, L. D.

Circulation, Vol 62, 704-711, Copyright © 1980 by American Heart Association

ARTICLES

Adrenergic responsiveness after abrupt propranolol withdrawal in normal subjects and in patients with angina pectoris

J Lindenfeld, MH Crawford, RA O'Rourke, SP Levine, MM Montiel and LD Horwitz

Adrenergic responsiveness after abrupt propranolol withdrawas during exogenous and esdogenous catecholamine stimulation was assessed in 10 normal subjects and 10 patients with angina pectoris. Propranolol, 160 mg/day, was administered for 2 weeks and then stopped. During an epinephrine infusion, period (p < 0.005). There were no differences from control 96 hours after the drug had been stopped in both groups or at 144 hours in the angina patients who were studied for a longer time. At 48 hours of heart rate and the pressure-rate product were significantly less than control level in the angina patient, but not in the normal subjects. Similar results were observed during exercise in both groups. The epinephrine-induced increase in free fatty acids was blocked by propranolol (p < 0.005), was still attenuated at 48 hours of withdrawals (p < 0.05), but returned to control levels thereafter in both groups. Resting serum triiodothyromine levels decreased with propranolol ( < 0.005) and remaind low throughout the withdrawal period. Measurements of dopamine beta-hydroxylase, plasma platelet factor 4, and platelet aggregation at rest and after exercise did not change significantly during or after propranolol administration. Plasma norepinephrine and epinephrine values were not changed from control during the withdrawal period at rest or after exerise. We conclude that there is no evidence of hypersensitivity to beta-adrenergically mediated responses after abrupt propranolol withdrawal.

This article has been cited by other articles:

				M. C. Gerson Reduction in dipyridamole-induced single-photon emission computed tomography myocardial defect size by beta-blockers: Time to re-examine the patient preparation protocol for pharmacologic stress testing J. Am. Coll. Cardiol., October 15, 2003; 42(8): 1484 - 1486. [Full Text] [PDF]

				S. Goldstein {beta}-Blockers in Hypertensive and Coronary Heart Disease Arch Intern Med, June 24, 1996; 156(12): 1267 - 1276. [Abstract] [PDF]

				J. K. Kirk and S. H. Johnson Safe Discontinuation of Antihypertensive Therapy Arch Fam Med, March 1, 1995; 4(3): 266 - 270. [Abstract] [PDF]

				C. F. WARD Otolaryngologists Using Local Anesthetics Containing Epinephrine Arch Otolaryngol Head Neck Surg, April 1, 1985; 111(4): 281 - 281. [Abstract] [PDF]

				H. Smulyan, S. E. Weinberg, and P. J. Howanitz Continuous Propranolol Infusion Following Abdominal Surgery JAMA, May 14, 1982; 247(18): 2539 - 2542. [Abstract] [PDF]