Circulation, Vol 60, 1220-1229, Copyright © 1979 by American Heart Association
JK Huttunen, E Lansimies, E Voutilainen, C Ehnholm, E Hietanen, I Penttila, O Siitonen and R Rauramaa
A controlled trial is reported on the effects of mild-to-moderate physical
activity on serum lipoproteins. After two baseline examinations 100
asymptomatic middle-aged men were randomly assigned to exercise and control
groups. The exercise group participated in a 4- month exercise program that
consisted of 3-4 weekly sessions. The control group was advised to maintain
their previous exercise habits. The success of the program was corroborated
by the increase in VO2 in the training group, but not in the control group.
Serum triglycerides decreased from 1.54 +/- 0.10 to 1.27 +/- 0.08 mmol/1 (p
less than 0.001) and high-density lipoprotein (HDL) cholesterol increased
from 1.27 +/- 0.04 to 1.41 +/- 0.04 mmol/1 (p less than 0.01) in the
exercise group during the trial. No change was seen in the control group.
As the concentration of apolipoprotein AI stayed constant in both groups,
the ratio HDL cholesterol/apolipoprotein AI increased only in the exercise
group. The level of low-density lipoprotein (LDL) cholesterol and
apolipoprotein AII decreased in both groups during the trial. The
alterations in serum triglycerides and HDL cholesterol in the exercise
group were not dependent on weight reduction; similar changes were also
seen in subjects with constant body weight during the intervention.
ARTICLES
Effect of moderate physical exercise on serum lipoproteins. A controlled clinical trial with special reference to serum high-density lipoproteins
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