Circulation, Vol 60, 1096-1104, Copyright © 1979 by American Heart Association
L Hatle, B Angelsen and A Tromsdal
The mean pressure drop across the mitral valve and atrioventricular
pressure half-time were measured noninvasively by Doppler ultrasound in 40
normal subjects, in 17 patients with mitral regurgitation, 32 patients with
mitral stenosis and 12 with combined stenosis and regurgitation. In normal
subjects pressure half-times were 20--60 msec, in patients with isolated
mitral regurgitation 35--80 msec and in patients with mitral stenosis
90--383 msec. There was no significant change in pressure half-time with
exercise or on repeat examinations, indicating relative independence of
mitral flow. In 25 patients with mitral stenosis and seven with combined
stenosis and regurgitation, pressure half-time was related to mitral valve
area calculated from catheterization data. Increasing pressure half-times
occurred with decreasing mitral valve area, and this relationship was not
influenced by additional mitral regurgitation. Noninvasive measurement of
pressure half-time together with mean pressure drop was useful for
evaluating patients with mitral valve disease.
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Noninvasive assessment of atrioventricular pressure half-time by Doppler ultrasound
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