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Circulation. 1979;59:412-416

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Circulation, Vol 59, 412-416, Copyright © 1979 by American Heart Association


ARTICLES

Ventricular aneurysms complicating coxsackievirus group B, types 1 and 4 murine myocarditis

MR El-Khatib, JL Chason and AM Lerner

Suckling Swiss Webster mice were inoculated with 10(4)TCD50 of coxsackieviruses, group B types 1 or 4. Virulent necrotizing myocarditis resulted in 185 infected mice. Of the latter group, three (14.3%) nurslings on the 17th and 23rd day after inoculations had left ventricular aneurysms postmortem. None of 61 concurrently matched control mice developed aneurysms. Ventricular aneurysm is a suggested but previously undocumented complication of murine, and possibly human necrotizing transmural coxsackievirus myocarditis.