Circulation, Vol 59, 412-416, Copyright © 1979 by American Heart Association
MR El-Khatib, JL Chason and AM Lerner
Suckling Swiss Webster mice were inoculated with 10(4)TCD50 of
coxsackieviruses, group B types 1 or 4. Virulent necrotizing myocarditis
resulted in 185 infected mice. Of the latter group, three (14.3%) nurslings
on the 17th and 23rd day after inoculations had left ventricular aneurysms
postmortem. None of 61 concurrently matched control mice developed
aneurysms. Ventricular aneurysm is a suggested but previously undocumented
complication of murine, and possibly human necrotizing transmural
coxsackievirus myocarditis.
ARTICLES
Ventricular aneurysms complicating coxsackievirus group B, types 1 and 4 murine myocarditis
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