This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Jengo, J. A. Articles by Mena, I. Search for Related Content PubMed PubMed Citation Articles by Jengo, J. A. Articles by Mena, I.

Circulation, Vol 59, 60-65, Copyright © 1979 by American Heart Association

ARTICLES

Effects of maximal exercise stress on left ventricular function in patients with coronary artery disease using first pass radionuclide angiocardiography: a rapid, noninvasive technique for determining ejection fraction and segmental wall motion

JA Jengo, V Oren, R Conant, M Brizendine, T Nelson, JM Uszler and I Mena

Angiographically determined changes in segmental wall motion (SWM) and ejection fraction (EF) are sensitive indices of left ventricular (LV) function. To compare the effects of exercise on LV function, first pass radionuclide angiocardiography was used before and during maximal upright bicycle stress in patients with nonsignificantly stenosed coronary arteries, and in those with greater than 75% stenosis. Gamma camera acquisitions were made in the 30 degree RAO projection using a 20 mCi I.V. bolus of 99mTc-pertechnetate. In the control group (seven normals, one nonsignificant (CAD) the EF significantly increased between rest and exercise (0.65 +/- 0.03 to 0.81 +/- 0.03 (mean +/- SEM), p less than 0.005). In this group SWM measured over the two anterior and two inferoposterior segments uniformly increased. In the 11 patients with a history of angina and significant coronary artery obstruction, the EF did not change in three and significantly decreased in the remaining eight (0.57 +/- 0.04 to 0.45 +/- 0.03, p less than 0.005). In all 11 patients SWM either decreased or did not increase in the areas supplied by the significantly stenosed coronary arteries. Upright maximal stress angiocardiography appears to be well-suited for diagnosing ischemic heart disease and localizing the area of ischemic dysfunction.

This article has been cited by other articles:

				T. J. Meine, M. W. Hanson, and S. Borges-Neto The Additive Value of Combined Assessment of Myocardial Perfusion and Ventricular Function Studies J. Nucl. Med., October 1, 2004; 45(10): 1721 - 1724. [Abstract] [Full Text] [PDF]

				R. Belardinelli, F. Lacalaprice, F. Carle, A. Minnucci, G. Cianci, G. Perna, and G. D'Eusanio Exercise-induced myocardial ischaemia detected by cardiopulmonary exercise testing Eur. Heart J., July 2, 2003; 24(14): 1304 - 1313. [Abstract] [Full Text] [PDF]

				K.M.A. Hussain, L. Gould, E.V. Pomerantsev, M. Angirekula, and T. Bharathan Comparative Study of Left Ventricular Function in Patients with Unstable Angina, Non-Q Wave Myocardial Infarction and Stable Angina Pectoris: Assessment with Atrial Pacing and Digital Ventriculography Angiology, October 1, 1995; 46(10): 867 - 876. [Abstract] [PDF]

				H. L. Sacher, M. L. Sacher, S. W. Landau, K. A. Dietrich, A. Chien, and F. Dooley First-Pass Radionuclide Cineangiography: A Reevaluation of Its Sensitivity and Limitations in the Detection of Significant Coronary Artery Disease Angiology, June 1, 1992; 43(6): 470 - 476. [Abstract] [PDF]

				J. Darsinos, J. Karli, A. Pistevos, G. Levis, and S. Moulopoulos Hemodialysis with Calcium-Free Dialysate Prevents Myocardial Creatine Kinase Depletion After Brief Coronary Artery Occlusion in Dogs Angiology, January 1, 1988; 39(10): 865 - 872. [Abstract] [PDF]

				H. G. Stratmann, A. L. Mark, K. E. Walter, J. W. Fletcher, and G. A. Williams Atrial Pacing and Thallium 201 Scintigraphy: Combined Use for Diagnosis of Coronary Artery Disease Angiology, November 1, 1987; 38(11): 807 - 814. [Abstract] [PDF]

				R. L. Lewis, J. S. Videll, M. D. Strong, V. Maranhao, and F. J. Lumia Exercise Radionuclide Assessment of Left Ventricular Function Before and After Coronary Bypass Surgery Angiology, August 1, 1987; 38(8): 601 - 608. [Abstract] [PDF]

				R. B. Whiting Lactic Dehydrogenase and Fraction 1 in Acute Myocardial Infarction Angiology, November 1, 1981; 32(11): 764 - 772. [PDF]

				J. De Cree, J. Leempoels, W. De Cock, H. Geukens, and H. Verhaegen The Antihypertensive Effects of a Pure and Selective Serotonin-Receptor Blocking Agent (R 41 468) in Elderly Patients Angiology, February 1, 1981; 32(2): 137 - 144. [Abstract] [PDF]