This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Maseri, A. Articles by De Nes, M. Search for Related Content PubMed PubMed Citation Articles by Maseri, A. Articles by De Nes, M.

Circulation, Vol 55, 423-433, Copyright © 1977 by American Heart Association

ARTICLES

Regional myocardial perfusion in patients with atherosclerotic coronary artery disease, at rest and during angina pectoris induced by tachycardia

A Maseri, A L'Abbate, A Pesola, C Michelassi, M Marzilli and M De Nes

We studied regional myocardial perfusion by scintigraphic computer- assisted analysis of initial distribution, washout rates, and residual activity of 133Xe injected into the left coronary artery of four patients with normal arteriograms and 14 patients with coronary stenosis. At rest, residual activity in poststenotic regions was always greater than in control regions, but initial washout rates were not slower. During angina, following xenon injections, the amount of indicator distributed to the poststenotic regions was markedly reduced; the increase of the initial washout rates was smaller than in control regions relative to rest, and residual activity was higher. Initial washout rates did not differ as much as from those of normal myocardium because in severe ischemia too little indicator is deposited initially in these regions to produce a change of any magnitude. Indeed, when angina was induced immediately after the xenon injection, poststenotic washout rates became much slower during angina than at rest, a finding that implicates functional factors in impairing poststenotic myocardial perfusion during angina.

This article has been cited by other articles:

				G. Sambuceti, M. Marzilli, A. Mari, C. Marini, M. Schluter, R. Testa, M. Papini, P. Marraccini, G. Ciriello, P. Marzullo, et al. Coronary microcirculatory vasoconstriction is heterogeneously distributed in acutely ischemic myocardium Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2298 - H2305. [Abstract] [Full Text] [PDF]

				G. Sambuceti, M. Marzilli, S. Fedele, C. Marini, and A. L'Abbate Paradoxical Increase in Microvascular Resistance During Tachycardia Downstream From a Severe Stenosis in Patients With Coronary Artery Disease : Reversal by Angioplasty Circulation, May 15, 2001; 103(19): 2352 - 2360. [Abstract] [Full Text] [PDF]

				G. Sambuceti, M. Marzilli, P. Marraccini, J. Schneider-Eicke, E. Gliozheni, O. Parodi, and A. L'Abbate Coronary Vasoconstriction During Myocardial Ischemia Induced by Rises in Metabolic Demand in Patients With Coronary Artery Disease Circulation, June 17, 1997; 95(12): 2652 - 2659. [Abstract] [Full Text]

				F. A. Anderson Jr., H. B. Wheeler, R. J. Goldberg, D. W. Hosmer, A. Forcier, and N. A. Patwardhan Physician Practices in the Prevention of Venous Thromboembolism Ann Intern Med, October 15, 1991; 115(8): 591 - 595. [Abstract] [PDF]

				R. M. Fuchs and L. C. Becker Pathogenesis of Angina Pectoris Arch Intern Med, September 1, 1982; 142(9): 1685 - 1692. [Abstract] [PDF]

				S. Conti and M. Daschbach Venous Thromboembolism Prophylaxis: A Survey of Its Use in the United States Arch Surg, August 1, 1982; 117(8): 1036 - 1040. [Abstract] [PDF]