Circulation, Vol 54, 774-779, Copyright © 1976 by American Heart Association
AJ Hordof, R Edie, JR Malm, BF Hoffman and MR Rosen
We used standard microelectrode techniques to record action potentials of
human right atrial fibers obtained during cardiac surgery, and correlated
these potentials with clinical and preoperative ECG data. Human atrial
fibers were classified as follows: Group A (ten patients) had a maximum
diastolic potential (MDP) of -71.4 +/- 5.1mV (mean +/- SD), and action
potentials that were primarily fast responses. These atria were normal or
slightly dilated. In group B (12 patients) MDP was 50.3 +/- 5.7 mV; action
potentials were slow responses and the atria were moderately to markedly
dilated. Atrial arrhythmias occurred in four group B and no group A
patients. The ECG revealed a signficant difference (P less than 0.005) in P
wave duration: group A, 89 +/- 3.0 msec; group B, 111 +/- 6.0 msec.
Verapamil, 0.1 mg/L, markedly depressed only the action potential plateau
of group A. Procainamide 1- 100 mg/L had equivalent effects on fibers of
both groups A and B, effects which were small at dosages of less than 40
mg/L. Procainamide did not depress slow response automaticity, but
verapamil (0.1-1 mg/L) did.
ARTICLES
Electrophysiologic properties and response to pharmacologic agents of fibers from diseased human atria
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