This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Olley, P. M. Articles by Bodach, E. Search for Related Content PubMed PubMed Citation Articles by Olley, P. M. Articles by Bodach, E.

Circulation, Vol 53, 728-731, Copyright © 1976 by American Heart Association

ARTICLES

E-type prostaglandins: a new emergency therapy for certain cyanotic congenital heart malformations

PM Olley, F Coceani and E Bodach

Prostaglandin E2 (PGE2) has been used to maintain patency of the ductus arteriosus in four neonates with cyanotic congenital heart disease due to obstructive right heart malformations. PGE2 was infused prior to surgery, and in three patients, during surgery until a satisfactory aorto-pulmonary shunt was established. PGE2 produced consistently an immediate and persistent rise in arterial oxygen saturation, which could be ascribed to dilation of the ductus arteriosus. No major side effects occurred, except for pyrexia in two infants. All patients recovered well from surgery. We propose this treatment as preparation for surgery in any infant with congenital heart defects and ductus- dependent pulmonary blood flow. The same treatment may be useful preoperatively in patients with aortic interruption who also depend on continued patency of the ductus for blood supply to the lower half of the body.

This article has been cited by other articles:

				G. Gargiulo, C. P. Napoleone, E. Angeli, and G. Oppido Neonatal coarctation repair using extended end-to-end anastomosis MMCTS, May 23, 2008; 2008(0523): 2691. [Abstract] [Full Text] [PDF]

				H. L. Walters III, C. E. Ionan, R. L. Thomas, and R. E. Delius Single-stage versus 2-stage repair of coarctation of the aorta with ventricular septal defect. J. Thorac. Cardiovasc. Surg., April 1, 2008; 135(4): 754 - 761. [Abstract] [Full Text] [PDF]

				A. T. Harder and Y. H. An The Mechanisms of the Inhibitory Effects of Nonsteroidal Anti-Inflammatory Drugs on Bone Healing: A Concise Review J. Clin. Pharmacol., August 1, 2003; 43(8): 807 - 815. [Abstract] [Full Text] [PDF]

				D.S. Lim, T. J. Kulik, D. W. Kim, J. R. Charpie, D. C. Crowley, and K. O. Maher Aminophylline for the Prevention of Apnea During Prostaglandin E1 Infusion Pediatrics, July 1, 2003; 112(1): e27 - 29. [Abstract] [Full Text] [PDF]

				P. M. Verheijen, L. A. Lisowski, P. Stoutenbeek, J. F. Hitchcock, J. I. Brenner, J. A. Copel, C. S. Kleinman, E. J. Meijboom, and G. B. W. E. Bennink Prenatal diagnosis of congenital heart disease affects preoperative acidosis in the newborn patient J. Thorac. Cardiovasc. Surg., April 1, 2001; 121(4): 798 - 803. [Abstract] [Full Text] [PDF]

				K. Ishino, M. Kawada, H. Irie, K. Kino, and S. Sano Single-stage repair of aortic coarctation with ventricular septal defect using isolated cerebral and myocardial perfusion Eur. J. Cardiothorac. Surg., May 1, 2000; 17(5): 538 - 542. [Abstract] [Full Text] [PDF]

				A. Jelly, A. Jelly, M. O. Galal, F. Al Fadley, M. de Moor, and Z. Al Halees Influence of Associated Defects and Type of Surgery in Neonatal Aortic Coarctation Asian Cardiovasc Thorac Ann, June 1, 1999; 7(2): 115 - 120. [Abstract] [Full Text] [PDF]

				S. Conte, F. Lacour-Gayet, A. Serraf, M. Sousa-Uva, J. Bruniaux, A. Touchot, C. Planche, and S. b. A. Castaneda Surgical management of neonatal coarctation J. Thorac. Cardiovasc. Surg., April 1, 1995; 109(4): 663 - 675. [Abstract] [Full Text]