This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Steele, P. Articles by Genton, E. Search for Related Content PubMed PubMed Citation Articles by Steele, P. Articles by Genton, E.

Circulation, Vol 53, 685-687, Copyright © 1976 by American Heart Association

ARTICLES

Correlation of platelet survival time with occlusion of saphenous vein aorto-coronary bypass grafts

P Steele, D Battock, G Pappas and E Genton

Platelet survival time is frequently shortened in patients with coronary artery disease, and it is one of several factors that might contribute to graft occlusion after saphenous vein coronary artery bypass (CAB). In 35 patients with CAB, average platelet survival (autologous labeling with 51Chromium) was shortened in 20 with one or more saphenous vein grafts occluded and normal in 15 with all grafts open. Of 15 with all grafts open, individual levels of platelet survival were normal in 10 while in 20 with one or more grafts occluded platelet survival was normal in only one. Platelet survival was not altered by coronary surgery and nine of ten with shortened platelet survival pre-operatively had graft occlusion. Platelet survival did not correlate with either parent artery occlusion or serum lipoproteins. These findings suggest a relationship between shortened platelet survival and saphenous vein graft occlusion and suggest that platelet suppressant therapy might be useful in preventing graft occlusion.

This article has been cited by other articles:

				W. C. Krupski and J. H. Rapp Smoking and Atherosclerosis Perspectives in Vascular Surgery and Endovascular Therapy, January 1, 1988; 1(1): 103 - 134. [PDF]