This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kerber, R. E. Articles by Abboud, F. M. Search for Related Content PubMed PubMed Citation Articles by Kerber, R. E. Articles by Abboud, F. M.

Circulation, Vol 52, 1097-1104, Copyright © 1975 by American Heart Association

ARTICLES

Correlation between echocardiographically demonstrated segmental dyskinesis and regional myocardial perfusion

RE Kerber, ML Marcus, J Ehrhardt, R Wilson and FM Abboud

In order to evaluate the relationship between regional myocardial perfusion and segmental dyskinesis, 22 open chest dogs were studied using ultrasound to register cardiac wall motion and radioactive labeled microspheres to determine myocardial perfusion. In six dogs, motion and perfusion were correlated at two levels of partial circumflex coronary artery occlusion followed by complete occlusion. A good correlation between declining myocardial perfusion of all the ischemic segments and development of aneurysmal bulging (during isometric contraction) was seen: r = minus 0.80. A similar correlation between myocardial perfusion and endocardial wall velocity (during systolic ejection) was observed: r = 0.92. In nine dogs, the effect of 45 minutes of complete coronary occlusion followed by 30 minutes of reperfusion was evaluated with respect to perfusion and motion. After coronary reperfusion myocardial perfusion of the ischemic area returned to control levels (from 32.6 +/- 3.5 to 130.3 +/- 13.3 ml/100 g/min), but aneurysmal bulging during isometric contraction persisted. Endocardial wall velocity during systolic ejection showed a variable response to reperfusion, achieving values ranging from 32% to 162% of the preocclusion levels. In seven dogs the ultrasound beam was reflected off nonischemic myocardium adjacent to areas of ischemia resulting from coronary occlusion. Despite preservation of normal myocardial perfusion in these nonischemic areas wall motion abnormalities were evident: endocardial wall velocity declined from 25.8 +/- 5.8 to 14.0 +/- 4.9 mm/sec (P less than 0.01), and aneurysmal bulging in three animals. These changes may be due to transient undetected ischemia in the segments struck by the ultrasound beam, or to passive alteration of the motion of the normally perfused areas by the severe dyskinesis of the adjacent ischemic myocardium.

This article has been cited by other articles:

				Y. Liu, H. Wen, R. C. Gorman, J. J. Pilla, J. H. Gorman III, G. Buckberg, S. D. Teague, and G. S. Kassab Reconstruction of myocardial tissue motion and strain fields from displacement-encoded MR imaging Am J Physiol Heart Circ Physiol, September 1, 2009; 297(3): H1151 - H1162. [Abstract] [Full Text] [PDF]

				M. Kay, L. Swift, B. Martell, A. Arutunyan, and N. Sarvazyan Locations of ectopic beats coincide with spatial gradients of NADH in a regional model of low-flow reperfusion Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H2400 - H2405. [Abstract] [Full Text] [PDF]

				B. D. Rosen, J. A.C. Lima, K. Nasir, T. Edvardsen, A. R. Folsom, S. Lai, D. A. Bluemke, and M. Jerosch-Herold Lower Myocardial Perfusion Reserve Is Associated With Decreased Regional Left Ventricular Function in Asymptomatic Participants of the Multi-Ethnic Study of Atherosclerosis Circulation, July 25, 2006; 114(4): 289 - 297. [Abstract] [Full Text] [PDF]

				J. S. Shanewise How to Reliably Detect Ischemia in the Intensive Care Unit and Operating Room Seminars in Cardiothoracic and Vascular Anesthesia, March 1, 2006; 10(1): 101 - 109. [Abstract] [PDF]

				H. Ashikaga, S. R. Mickelsen, D. B. Ennis, I. Rodriguez, P. Kellman, H. Wen, and E. R. McVeigh Electromechanical analysis of infarct border zone in chronic myocardial infarction Am J Physiol Heart Circ Physiol, September 1, 2005; 289(3): H1099 - H1105. [Abstract] [Full Text] [PDF]

				T. Edvardsen, O. Rodevand, K. Endresen, and H. Ihlen Interaction between left ventricular wall motion and intraventricular flow propagation in acute and chronic ischemia Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H732 - H737. [Abstract] [Full Text] [PDF]

				H. Leong-Poi, M. P. Coggins, J. Sklenar, A. R. Jayaweera, X.-Q. Wang, and S. Kaul Role of collateral blood flow in the apparent disparity between the extent of abnormal wall thickening and perfusion defect size during acute myocardial infarction and demand ischemia J. Am. Coll. Cardiol., February 15, 2005; 45(4): 565 - 572. [Abstract] [Full Text] [PDF]

				Y. Zhang, J. W. Bissing, L. Xu, A. J. Ryan, S. M. Martin, F. J. Miller Jr, K. C. Kregel, G. R. Buettner, and R. E. Kerber Nitric oxide synthase inhibitors decrease coronary sinus-free radical concentration and ameliorate myocardial stunning in an ischemia-reperfusion model J. Am. Coll. Cardiol., August 1, 2001; 38(2): 546 - 554. [Abstract] [Full Text] [PDF]

				H. B. Hillenbrand, R. J. Kim, M. A. Parker, D. S. Fieno, and R. M. Judd Early Assessment of Myocardial Salvage by Contrast-Enhanced Magnetic Resonance Imaging Circulation, October 3, 2000; 102(14): 1678 - 1683. [Abstract] [Full Text] [PDF]

				G. Derumeaux, M. Ovize, J. Loufoua, G. Pontier, X. Andre-Fouet, and A. Cribier Assessment of Nonuniformity of Transmural Myocardial Velocities by Color-Coded Tissue Doppler Imaging : Characterization of Normal, Ischemic, and Stunned Myocardium Circulation, March 28, 2000; 101(12): 1390 - 1395. [Abstract] [Full Text] [PDF]

				G. Derumeaux, M. Ovize, J. Loufoua, X. Andre-Fouet, Y. Minaire, A. Cribier, and B. Letac Doppler Tissue Imaging Quantitates Regional Wall Motion During Myocardial Ischemia and Reperfusion Circulation, May 19, 1998; 97(19): 1970 - 1977. [Abstract] [Full Text] [PDF]