1 From the Masonic Medical Research Laboratory, Utica, New York.
Isolated blocks of dog atrial tissue were dissected to provide a narrow isthmus connecting two broader areas. Unidirectional block was readily demonstrable at the junctions of the narrow band with the larger areas. Transmembrane action potentials just proximal to the blocked junction were abbreviated, while only local electronic potentials were recorded beyond. Acetylcholine restored 1:1 propagation in blocked preparations. The model may explain some of the features of intermittent preexcitation.
Submitted on December 7, 1970
© 1971 American Heart Association, Inc.
Conduction through a Narrow Isthmus in Isolated Canine Atrial Tissue
A Model of the W-P-W Syndrome
Key Words: Acetylcholine and atrial conduction • Conduction block • Preexcitation syndrome
Accepted on July 15, 1971
This article has been cited by other articles:
 |
|
 |
|
  J.#x.;n. Farré, H. J.J. Wellens, J.#x. M. Rubio, and J. Benezet CHAPTER 28 Supraventricular Tachycardias ESC Textbook of Cardiovascular Medicine, January 1, 2009; 2(1): med-9780199566990-chapter - med-9780199566990-chapter. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. R. Laurita and D. S. Rosenbaum Interdependence of Modulated Dispersion and Tissue Structure in the Mechanism of Unidirectional Block Circ. Res., November 10, 2000; 87(10): 922 - 928. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Miyauchi, Y. Kobayashi, T. Ino, and H. Atarashi Local slow potential preceding the surface QRS complex detected at the subvalvular mitral annulus in patients with a left-sided concealed accessory pathway. Incidence, electrophysiological characteristics and the possible mechanism, with demonstration of anterograde concealed conduction through the pathway Eur. Heart J., December 2, 1999; 20(24): 1818 - 1825. [Abstract] [PDF]
|
|
|
|
 |
|
 S.-A. Chen, M.-H. Hsieh, C.-T. Tai, C.-F. Tsai, V. S. Prakash, W.-C. Yu, T.-L. Hsu, Y.-A. Ding, and M.-S. Chang Initiation of Atrial Fibrillation by Ectopic Beats Originating From the Pulmonary Veins : Electrophysiological Characteristics, Pharmacological Responses, and Effects of Radiofrequency Ablation Circulation, November 2, 1999; 100(18): 1879 - 1886. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-H. Kim, F. Xie, M. Yashima, T.-J. Wu, M. Valderrabano, M.-H. Lee, T. Ohara, O. Voroshilovsky, R. N. Doshi, M. C. Fishbein, et al. Role of Papillary Muscle in the Generation and Maintenance of Reentry During Ventricular Tachycardia and Fibrillation in Isolated Swine Right Ventricle Circulation, September 28, 1999; 100(13): 1450 - 1459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-H. Kim, M. Yashima, T.-J. Wu, R. Doshi, P.-S. Chen, and H. S. Karagueuzian Mechanism of Procainamide-Induced Prevention of Spontaneous Wave Break During Ventricular Fibrillation : Insight Into the Maintenance of Fibrillation Wave Fronts Circulation, August 10, 1999; 100(6): 666 - 674. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yoshida, H. Ikeda, T. Hiraki, I. Kubara, M. Ohga, and T. Imaizumi Detection of concealed left sided accessory atrioventricular pathway by P wave signal averaged electrocardiogram J. Am. Coll. Cardiol., January 1, 1999; 33(1): 55 - 62. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Athill, T. Ikeda, Y.-H. Kim, T.-J. Wu, M. C. Fishbein, H. S. Karagueuzian, and P.-S. Chen Transmembrane Potential Properties at the Core of Functional Reentrant Wave Fronts in Isolated Canine Right Atria Circulation, October 13, 1998; 98(15): 1556 - 1567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ikeda, L. Czer, A. Trento, C. Hwang, J. J. C. Ong, D. Hough, M. C. Fishbein, W. J. Mandel, H. S. Karagueuzian, and P.-S. Chen \E Induction of Meandering Functional Reentrant Wave Front in Isolated Human Atrial Tissues Circulation, November 4, 1997; 96(9): 3013 - 3020. [Abstract] [Full Text]
|
|
|
|
 |
|
 K.-C. Ueng, S.-A. Chen, C.-E. Chiang, C.-C. Cheng, T.-J. Wu, C.-T. Tai, S.-H. Lee, C.-W. Chiou, C.-Y. Chen, Z.-C. Wen, et al. Paradox of Accessory Pathway Block After Radiofrequency Ablation in Patients with the Wolff-Parkinson-White Syndrome Angiology, November 1, 1996; 47(11): 1061 - 1071. [Abstract] [PDF]
|
|
|
|
|
|
T. Ikeda, T. Uchida, D. Hough, J. J. Lee, M. C. Fishbein, W. J. Mandel, P.-S. Chen, and H. S. Karagueuzian Mechanism of Spontaneous Termination of Functional Reentry in Isolated Canine Right Atrium: Evidence for the Presence of an Excitable but Nonexcited Core Circulation, October 15, 1996; 94(8): 1962 - 1973. [Abstract] [Full Text]
|
|
|
|
|
|
S.-A. Chen, C.-E. Chiang, C.-T. Tai, S.-H. Lee, C.-W. Chiou, K.-C. Ueng, Z.-C. Wen, C.-C. Cheng, and M.-S. Chang Longitudinal Clinical and Electrophysiological Assessment of Patients With Symptomatic Wolff-Parkinson-White Syndrome and Atrioventricular Node Reentrant Tachycardia Circulation, June 1, 1996; 93(11): 2023 - 2032. [Abstract] [Full Text]
|
|
|
|
 |
|
 F.-Y. Lin, J.-H. Huang, J.-L. Lin, W.-J. Chen, H.-M. Lo, and S.-H. Chu ATRIAL COMPARTMENT SURGERY FOR CHRONIC ATRIAL FIBRILLATION ASSOCIATED WITH CONGENITAL HEART DEFECTS J. Thorac. Cardiovasc. Surg., January 1, 1996; 111(1): 231 - 237. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. C. HINDMAN, J. H. LAST, and K. M. ROSEN Wolff-Parkinson-White Syndrome Observed by Portable Monitoring Ann Intern Med, November 1, 1973; 79(5): 654 - 663. [Abstract] [PDF]
|
|