1 From the Department of Cardiology, Cedars-Sinai Medical Center, and the Department of Medicine, University of California, Los Angeles, California.
A technique was developed for measurement of blood flow in the coronary sinus in man by continuous thermodilution. For single determinations, 5% dextrose at room temperature is injected at a constant rate of 35 ml/min for a period of about 20 sec. In 14 subjects with normal coronary arteries the mean coronary sinus blood flow was 122 ± 25 ml/min (range, 83 to 159 ml/min). The blood flow computed per 100 g of left ventricle was 82 ± 16 ml/min, which is in the range of values obtained by nitrous oxide and coincidence counting methods. In 35 patients with arteriographically confirmed coronary artery disease the mean flow was similar (128 ± 20 ml/min; range, 92 to 167 ml/min). A special catheter was used for simultaneous measurement of blood flow in the coronary sinus and great cardiac vein. In eight normal subjects the mean great cardiac vein flow was 68 ± 11 ml/min (range, 51 to 78 ml/min) or 65 ± 10% of the coronary sinus blood flow. The method allowed continuous measurement of flow over a period of several minutes and, for the first time, measurement of rapid changes in myocardial perfusion.
Submitted on January 29, 1971
© 1971 American Heart Association, Inc.
Measurement of Coronary Sinus Blood Flow by Continuous Thermodilution in Man
Key Words: Coronary blood flow in coronary artery disease • Regional myocardial blood flow • Temperature of blood in coronary sinus and right atrium • Recirculation • Turbulent flow
Accepted on April 2, 1971
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