1 From the Cardiovascular Research Laboratories, Department of Nutrition, Harvard School of Public Health, and the Levine Cardiac Unit, Cardiovascular Division, Department of Medicine, Peter Bent Brigham Hospital, Boston, Massachusetts.
Sudden cardiac death (SCD) continues unabated. Coronary care units, while effective in lowering hospital mortality, cannot significantly reduce SCD which occurs primarily outside the hospital and accounts for the majority of deaths from coronary heart disease (CHD). In view of the frequent precipitous nature of SCD, only a program which identifies and protects the victim prior to the event can hope to be successful in preventing the majority of SCD. Since it is likely that SCD is due to an arrhythmia, drug prophylaxis might prove effective. In view of the toxicity of currently available agents, it is mandatory to preselect a population at highest risk before embarking on a drug trial. Ventricular premature beats (VPB) may identify subjects susceptible to SCD. Epidemiologic and physiologic information on VPB is reviewed, and proposals are made for studies designed to establish the usefulness of VPB as a risk factor for SCD.
© 1971 American Heart Association, Inc.
Approaches to Sudden Death from Coronary Heart Disease
Key Words: Antiarrhythmic drugs • Ventricular premature beats • Exercise • Risk factors • Ventricular fibrillation
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M. Mirowski, M. M. Mower, W. S. Staewen, R. H. Denniston, and A. I. Mendeloff The Development of the Transvenous Automatic Defibrillator Arch Intern Med, May 1, 1972; 129(5): 773 - 779. [Abstract] [PDF]
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H. M. Sommers and R. B. Jennings Ventricular Fibrillation and Myocardial Necrosis After Transient Ischemia: Effect of Treatment With Oxygen, Procainamide, Reserpine, and Propranolol Arch Intern Med, May 1, 1972; 129(5): 780 - 789. [Abstract] [PDF]
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