This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by STORMONT, J. M. Articles by WATERHOUSE, C. Search for Related Content PubMed Articles by STORMONT, J. M. Articles by WATERHOUSE, C.

(Circulation. 1961;24:191.)
© 1961 American Heart Association, Inc.

---

The Genesis of Hyponatremia Associated with Marked Overhydration and Water Intoxication

JAMES M. STORMONT M.D.¹ CHRISTINE WATERHOUSE M.D.¹

¹ From the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York.

Prolonged overhydration and hyponatremia have been produced in 10 patients with use of Pitressin Tannate in Oil. Balance studies have shown that in patients who developed moderate hyponatremia, the drop in serum sodium could be explained by water retention. In patients who developed severe water intoxication, the very low levels of serum sodium (100-114 mEq./L.) could not be entirely accounted for by changes in salt and water balance.

Certain patients failed to develop severe water intoxication although an equivalent degree of overhydration was achieved. In these subjects, further overhydration was limited by intermittent episodes of low solute diuresis. This diuretic escape from Pitressin effect has been evaluated by measurement of U/P osmolar ratio on 24-hour urine specimens as well as T^cH₂O during hypertonic mannitol infusion. Defects in both aspects of renal concentration were observed, although they were not necessarily coexistent.

This article has been cited by other articles:

				G. Decaux and W. Musch Clinical Laboratory Evaluation of the Syndrome of Inappropriate Secretion of Antidiuretic Hormone Clin. J. Am. Soc. Nephrol., July 1, 2008; 3(4): 1175 - 1184. [Abstract] [Full Text] [PDF]