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(Circulation. 1957;15:245.)
© 1957 American Heart Association, Inc.

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Measurement of Cardiac Output and Central Volume by a Modified Decholin Test of Circulation Time

HADLEY L. CONN JR. M.D.¹; DONALD F. HEIMAN M.D.¹; CLAUDE R. JOYNER M.D.¹

¹ From The Robinette Foundation, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pa.

A technic is described for determining mean circulation time, cardiac output, and central blood volume by use of graded dosages of sodium dehydrocholate (Decholin) administered into a peripheral vein. The indicator-dilution curves derived by the technic were compared with radiopotassium-dilution curves obtained simultaneously in 12 patients. The results showed a surprisingly good agreement between the 2 methods and indicate that the traditional Decholin test of circulation time can be modified to provide much more information than it has in the past.