This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by CONN, H. L. Articles by FARR, L. E. Search for Related Content PubMed PubMed Citation Articles by CONN, H. L., JR. Articles by FARR, L. E.

(Circulation. 1955;12:1043.)
© 1955 American Heart Association, Inc.

---

The Effect of Large Intravenous Doses of Sodium Borate on the Human Myocardium as Reflected in the Electrocardiogram

HADLEY L. CONN JR. M.D.¹; BERNIECE B. ANTAL M.S.¹; LEE E. FARR M.D.¹

¹ From the Brookhaven National laboratory, Long Island, N. Y.

Large intravenous doses of sodium borate, given to seven patients with brain tumors, caused development of temporary but consistent hypoxic-type abnormalities in the S-T segments and the T waves of the electrocardiogram. Correlation of these electrocardiographic changes with blood boron concentrations, determined up to 48 hours after boron injection, indicated that the changes were probably the result of damage by boron, present intracellularly in the myocardium. The intracellular concentrations which cause electrocardiographic abnormalities are considered to be of the order of 100 µg. per milliliter, similar to concentrations which have been shown to inhibit respiration in in vitro myocardial preparations.

This article has been cited by other articles:

				6 Final Report on the Safety Assessment of Sodium Borate and Boric Acid International Journal of Toxicology, December 1, 1983; 2(7): 87 - 125. [Abstract] [PDF]