This Article Full Text Full Text (PDF) All Versions of this Article: 119/24/3118    most recent CIRCULATIONAHA.108.836163v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Baccarelli, A. Articles by Schwartz, J. Search for Related Content PubMed PubMed Citation Articles by Baccarelli, A. Articles by Schwartz, J. Related Collections Deep vein thrombosis Thrombosis risk factors Epidemiology Related Articles

(Circulation. 2009;119:3118-3124.)
© 2009 American Heart Association, Inc.

Vascular Medicine

Living Near Major Traffic Roads and Risk of Deep Vein Thrombosis

Andrea Baccarelli, MD; Ida Martinelli, MD, PhD; Valeria Pegoraro, BStat; Steven Melly, MS; Paolo Grillo, MD; Antonella Zanobetti, PhD; Lifang Hou, MD; Pier Alberto Bertazzi, MD; Pier Mannuccio Mannucci, MD; Joel Schwartz, PhD

From the Department of Environmental and Occupational Health (A.B., V.P., P.G., P.A.B.), and A. Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Medicine and Medical Specialties (I.M., P.M.M.), Istituto di Ricovero e Cura a Carattere Scientifico Maggiore Policlinico Hospital, Mangiagalli and Regina Elena Foundation and University of Milan, Milan, Italy, Department of Environmental Health, Harvard School of Public Health, Boston, Mass (A.B., S.M., A.Z., J.S.), and Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Ill (L.H.).

Correspondence to Dr Andrea Baccarelli, EPOCA Research Center for Environmental and Occupational Epidemiology, Department of Environmental and Occupational Health, Via San Barnaba 8, 20122 Milan, Italy. E-mail andrea.baccarelli{at}unimi.it

Received November 15, 2008; accepted April 6, 2009.

Background— Particulate air pollution has been consistently linked to increased risk of arterial cardiovascular disease. Few data on air pollution exposure and risk of venous thrombosis are available. We investigated whether living near major traffic roads increases the risk of deep vein thrombosis (DVT), using distance from roads as a proxy for traffic exposure.

Methods and Results— From 1995 through 2005, we examined 663 patients with DVT of the lower limbs and 859 age-matched controls from cities with population >15 000 inhabitants in Lombardia Region, Italy. We assessed distance from residential addresses to the nearest major traffic road using geographic information system methodology. The risk of DVT was estimated from logistic regression models adjusting for multiple clinical and environmental covariates. The risk of DVT was increased (odds ratio=1.33; 95% confidence interval, 1.03 to 1.71; P=0.03 in age-adjusted models; odds ratio=1.47; 95% confidence interval, 1.10 to 1.96; P=0.008 in models adjusted for multiple covariates) for subjects living near a major traffic road (index distance of 3 meters, 10th centile of the distance distribution) compared with those living farther away (reference distance of 245 meters, 90th centile). The increase in DVT risk was approximately linear over the observed distance range (from 718 to 0 meters) and was not modified after adjusting for background levels of particulate matter (odds ratio=1.47; 95% confidence interval, 1.11 to 1.96; P=0.008 for 10th versus 90th distance centile in models adjusting for area levels of particulate matter <10 µm in aerodynamic diameter in the year before diagnosis).

Conclusions— Living near major traffic roads is associated with increased risk of DVT.

---

 

CLINICAL PERSPECTIVE

Related Articles:

Circulation: Clinical Summaries
Circulation 2009 119: 3041-3043. [Extract] [Full Text]

The Expanding Role of Air Pollution in Cardiovascular Disease: Does Air Pollution Contribute to Risk of Deep Vein Thrombosis?

C. Arden Pope, III
Circulation 2009 119: 3050-3052. [Extract] [Full Text]

This article has been cited by other articles:

				A. Peters Air Quality and Cardiovascular Health: Smoke and Pollution Matter Circulation, September 15, 2009; 120(11): 924 - 927. [Full Text] [PDF]

				C. A. Pope III The Expanding Role of Air Pollution in Cardiovascular Disease: Does Air Pollution Contribute to Risk of Deep Vein Thrombosis? Circulation, June 23, 2009; 119(24): 3050 - 3052. [Full Text] [PDF]