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(Circulation. 2009;119:1758-1767.)
© 2009 American Heart Association, Inc.

Imaging

Detection and Quantification of Left Atrial Structural Remodeling With Delayed-Enhancement Magnetic Resonance Imaging in Patients With Atrial Fibrillation

Robert S. Oakes, BS; Troy J. Badger, MD; Eugene G. Kholmovski, PhD; Nazem Akoum, MD; Nathan S. Burgon, BS; Eric N. Fish; Joshua J.E. Blauer, BS; Swati N. Rao; Edward V.R. DiBella, PhD; Nathan M. Segerson, MD; Marcos Daccarett, MD; Jessiciah Windfelder, NP; Christopher J. McGann, MD; Dennis Parker, PhD; Rob S. MacLeod, PhD; Nassir F. Marrouche, MD

From the Atrial Fibrillation Program, University of Utah School of Medicine (R.S.O., T.J.B., E.G.K., N.A., N.S.B., E.N.F., J.J.E.B., S.N.R., E.V.R.D., N.M.S., M.D., J.W., C.J.M., R.S.M., N.F.M.), and Scientific Computing Institute (R.S.O., J.J.E.B., R.S.M.) and Utah Center for Advanced Imaging Research (E.G.K., E.V.R.D., C.J.M., D.P.), University of Utah, Salt Lake City.

Correspondence to Nassir F. Marrouche, MD, Director, Cardiac Electrophysiology Laboratories, Director, Atrial Fibrillation Program, Division of Cardiology, University of Utah Health Sciences Center, 30 N 1900 E, Room 4A100, Salt Lake City, UT 84132-2400. E-mail Nassir.Marrouche{at}hsc.utah.edu

Received March 27, 2008; accepted January 21, 2009.

Background— Atrial fibrillation (AF) is associated with diffuse left atrial fibrosis and a reduction in endocardial voltage. These changes are indicators of AF severity and appear to be predictors of treatment outcome. In this study, we report the utility of delayed-enhancement magnetic resonance imaging (DE-MRI) in detecting abnormal atrial tissue before radiofrequency ablation and in predicting procedural outcome.

Methods and Results— Eighty-one patients presenting for pulmonary vein antrum isolation for treatment of AF underwent 3-dimensional DE-MRI of the left atrium before the ablation. Six healthy volunteers also were scanned. DE-MRI images were manually segmented to isolate the left atrium, and custom software was implemented to quantify the spatial extent of delayed enhancement, which was then compared with the regions of low voltage from electroanatomic maps from the pulmonary vein antrum isolation procedure. Patients were assessed for AF recurrence at least 6 months after pulmonary vein antrum isolation, with an average follow-up of 9.6±3.7 months (range, 6 to 19 months). On the basis of the extent of preablation enhancement, 43 patients were classified as having minimal enhancement (average enhancement, 8.0±4.2%), 30 as having moderate enhancement (21.3±5.8%), and 8 as having extensive enhancement (50.1±15.4%). The rate of AF recurrence was 6 patients (14.0%) with minimal enhancement, 13 (43.3%) with moderate enhancement, and 6 (75%) with extensive enhancement (P<0.001).

Conclusions— DE-MRI provides a noninvasive means of assessing left atrial myocardial tissue in patients suffering from AF and might provide insight into the progress of the disease. Preablation DE-MRI holds promise for predicting responders to AF ablation and may provide a metric of overall disease progression.

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CLINICAL PERSPECTIVE

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Clinical Summaries
Circulation 2009 119: 1691-1693. [Extract] [Full Text]

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