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(Circulation. 2008;118:S94-S105.)
© 2008 American Heart Association, Inc.

Cardiac Transplantation and Surgery for Heart Failure

Prediction of Cardiac Stability After Weaning From Left Ventricular Assist Devices in Patients With Idiopathic Dilated Cardiomyopathy

Michael Dandel, MD, PhD; Yuguo Weng, MD, PhD; Henryk Siniawski, MD, PhD; Evgenij Potapov, MD; Thorsten Drews, MD; Hans B. Lehmkuhl, MD; Christoph Knosalla, MD, PhD; Roland Hetzer, MD, PhD

From the Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum, Berlin, Germany.

Correspondence to Michael Dandel, MD, PhD, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353 Berlin, Germany. E-mail dandel{at}dhzb.de

Background— During ventricular assist device (VAD) unloading, cardiac recovery is possible even in patients with chronic heart failure (HF). We sought parameters predictive of cardiac stability after VAD removal.

Methods and Results— Among 81 patients weaned since March 1995, a homogenous group of 35 with idiopathic dilated cardiomyopathy weaned from left VADs was selected. We evaluated echo data obtained before left VAD implantation and during "off-pump" trials before explantation, histological changes, and serum anti-β1-adrenoceptor-autoantibody disappearance during unloading, duration of unloading, and HF duration. Postweaning 10-year survival with native hearts reached 70.7±9.2%. During the first 5 years, HF recurred in 13 patients (37.1%). Only 6 (17.1%) died after HF recurrence or noncardiac complications related to left VAD explantation. Comparison of patients with and without long-term cardiac stability showed that stable patients were younger, HF history and recovery time during unloading shorter, and preweaning left ventricular assessment revealed higher left ventricular ejection fraction, lower short/long axis ratios, and higher end diastolic relative wall thicknesses. For left ventricular ejection fraction 45% at end diastolic diameter of 55 mm, predictive value for 5-year cardiac stability was 87.5%. Left ventricular ejection fraction time course during the first 6 postweaning months appeared predictive for long-term stability. HF history >5 years and preweaning instability of cardiac improvement appeared predictive for HF recurrence.

Conclusions— In idiopathic dilated cardiomyopathy, left VAD removal can be successful for >12 years even with incomplete cardiac recovery. Pre-explantation left ventricular ejection fraction, left ventricular end diastolic diameter and relative wall thicknesses, stability of unloading-induced cardiac recovery, duration of left VAD support, and HF duration before left VAD insertion allow identification of patients able to remain stable for >5 years. Time course of left ventricular ejection fraction during the first 6 postweaning months allows prognostic assessment.

Key Words: cardiomyopathy • echocardiography • heart failure • outcome • ventricular assist device

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