Published online before print August 13, 2007, doi: 10.1161/CIRCULATIONAHA.107.699447
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Circulation. 2007;116:1032-1040.)
© 2007 American Heart Association, Inc.
Pediatric Cardiology |
Impact of Repeated Dietary Counseling Between Infancy and 14 Years of Age on Dietary Intakes and Serum Lipids and Lipoproteins
The STRIP Study
From the Departments of Pediatrics (H.N., K.N.-S., O.S.), Medicine (T.R., J.V.), and Clinical Physiology (O.T.R.) and Research Centre of Applied and Preventive Cardiovascular Medicine (H.L., M.S.), University of Turku, Turku; National Public Health Institute, Turku (A.J., J.M.); and Department of Paediatrics, University of Helsinki, Helsinki (E.J.), Finland.
Reprint requests to Harri Niinikoski, MD, PhD, Department of Pediatrics, University of Turku, Kiinamyllynkatu 4–8, 20520 Turku, Finland. E-mail harri.niinikoski{at}tyks.fi
Received February 27, 2007; accepted June 15, 2007.
Background— Atherosclerosis development might be delayed or prevented by dietary measures. The aims of the present study were to evaluate the effect of low-saturated-fat, low-cholesterol dietary counseling on fat intakes, growth, serum cholesterol values, and pubertal development in children and adolescents.
Methods and Results— In the randomized prospective Special Turku Coronary Risk Factor Intervention Project (STRIP), a low-saturated-fat, low-cholesterol diet was introduced to intervention infants (n=540) at 7 months of age, and control children (n=522) received an unrestricted diet. Dietary intakes, serum cholesterol values, somatic growth, and development were followed up throughout childhood and adolescence. Saturated fat intakes, serum total cholesterol, and low-density lipoprotein cholesterol values were lower (P<0.001) in the intervention than in control children during the 14 years, whereas high-density lipoprotein cholesterol values in the 2 study groups showed no difference. Boys had lower total and low-density lipoprotein cholesterol concentrations than girls throughout childhood (P<0.001), and the intervention effect on serum cholesterol concentration was larger in boys than girls. The 2 study groups showed no difference in growth, body mass index, pubertal development, or age at menarche (median, 13.0 and 12.8 years in the intervention and control girls, respectively; P=0.52). The cholesterol values decreased as puberty progressed. Mean concentrations of total and high-density lipoprotein cholesterol decreased from 
4.5 and 1.4 mmol/L, respectively, in Tanner stage 1 (prepubertal) boys to 3.9 and 1.1 mmol/L in Tanner stage 4 (late pubertal) boys.
Conclusions— Repeated dietary counseling remains effective in decreasing saturated fat and cholesterol intake and serum cholesterol values at least until 14 years of age. Puberty markedly influences serum cholesterol concentrations.
CLINICAL PERSPECTIVE
Find additional patient-related information at:
Related Article:
-
Issue Highlights
Circulation 2007 116: 969.[Extract] [Full Text]
This article has been cited by other articles:
 |
|
 |
|
  O. Simell, H. Niinikoski, T. Ronnemaa, O. T Raitakari, H. Lagstrom, M. Laurinen, M. Aromaa, P. Hakala, A. Jula, E. Jokinen, et al. Cohort Profile: The STRIP Study (Special Turku Coronary Risk Factor Intervention Project), an Infancy-onset Dietary and Life-style Intervention Trial Int. J. Epidemiol., June 1, 2009; 38(3): 650 - 655. [Full Text] [PDF]
|
|
|
|
 |
|
 H. Niinikoski, A. Jula, J. Viikari, T. Ronnemaa, P. Heino, H. Lagstrom, E. Jokinen, and O. Simell Blood Pressure Is Lower in Children and Adolescents With a Low-Saturated-Fat Diet Since Infancy: The Special Turku Coronary Risk Factor Intervention Project Hypertension, June 1, 2009; 53(6): 918 - 924. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hakanen, O. T. Raitakari, T. Lehtimaki, N. Peltonen, K. Pahkala, L. Sillanmaki, H. Lagstrom, J. Viikari, O. Simell, and T. Ronnemaa FTO Genotype Is Associated with Body Mass Index after the Age of Seven Years But Not with Energy Intake or Leisure-Time Physical Activity J. Clin. Endocrinol. Metab., April 1, 2009; 94(4): 1281 - 1287. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kallio, E. Jokinen, M. Hamalainen, M. Saarinen, I. Volanen, T. Kaitosaari, J. Viikari, T. Ronnemaa, O. Simell, and O. T. Raitakari Decreased Aortic Elasticity in Healthy 11-Year-Old Children Exposed to Tobacco Smoke Pediatrics, February 1, 2009; 123(2): e267 - e273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Pahkala, O. J. Heinonen, H. Lagstrom, P. Hakala, O. Simell, J. S.A. Viikari, T. Ronnemaa, M. Hernelahti, L. Sillanmaki, and O. T. Raitakari Vascular Endothelial Function and Leisure-Time Physical Activity in Adolescents Circulation, December 2, 2008; 118(23): 2353 - 2359. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Steinberg, C. K. Glass, and J. L. Witztum Evidence Mandating Earlier and More Aggressive Treatment of Hypercholesterolemia Circulation, August 5, 2008; 118(6): 672 - 677. [Full Text] [PDF]
|
|
|
|
 |
|
 J. Sanz, P. R. Moreno, and V. Fuster The year in atherothrombosis. J. Am. Coll. Cardiol., March 4, 2008; 51(9): 944 - 955. [Full Text] [PDF]
|
|
|
|
|
|
H. C. McGill Jr, C. A. McMahan, and S. S. Gidding Preventing Heart Disease in the 21st Century: Implications of the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Study Circulation, March 4, 2008; 117(9): 1216 - 1227. [Full Text] [PDF]
|
|
|
|
|
|
S. R. Daniels Diet and Primordial Prevention of Cardiovascular Disease in Children and Adolescents Circulation, August 28, 2007; 116(9): 973 - 974. [Full Text] [PDF]
|
|