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(Circulation. 2007;116:1367-1373.)
© 2007 American Heart Association, Inc.

Epidemiology

Brachial Artery Flow-Mediated Dilation and Asymmetrical Dimethylarginine in the Cardiovascular Risk in Young Finns Study

Markus Juonala, MD, PhD; Jorma S.A. Viikari, MD, PhD; Georg Alfthan, PhD; Jukka Marniemi, PhD; Mika Kähönen, MD, PhD; Leena Taittonen, MD, PhD; Tomi Laitinen, MD, PhD; Olli T. Raitakari, MD, PhD

From the University of Turku, Departments of Medicine (M.J., J.S.A.V.) and Clinical Physiology (O.T.R.), Turku, Finland; Department of Health and Functional Ability (G.A), National Public Health Institute, Helsinki, Helsinki, Finland; Department of Health and Functional Capacity (J.M.), National Public Health Institute, Turku, Turku, Finland; Department of Clinical Physiology (M.K.), University of Tampere, Tampere, Finland; Department of Pediatrics (L.T.), Vaasa Central Hospital, Vaasa, Finland; Department of Pediatrics (L.T.), University of Oulu, Oulu, Finland; and Department of Clinical Physiology (T.L.), University of Kuopio, Kuopio, Finland.

Correspondence to Olli T. Raitakari, Department of Clinical Physiology, University of Turku, PO Box 52, 20521 Turku, Finland. E-mail olli.raitakari{at}utu.fi

Received January 12, 2007; accepted July 3, 2007.

Background— Elevated asymmetrical dimethylarginine (ADMA) is a novel risk factor for atherosclerosis that may impair endothelial function by interfering with endothelial nitric oxide synthesis. To gain insight into the effects of ADMA on systemic endothelial function, we examined the association between ADMA and brachial artery flow-mediated dilation (FMD) in a large population of young adults.

Methods and Results— Plasma ADMA and brachial FMD, as well as conventional cardiovascular risk factors, were measured in 2096 white adults aged 24 to 39 years. In univariate analysis, ADMA was inversely correlated with FMD (r=–0.07, P=0.003). The inverse association between ADMA and FMD remained significant in a multivariable regression model adjusted for age, sex, conventional cardiovascular risk factors, estimated glomerular filtration rate, and brachial artery baseline diameter (ß±SE –1.56±0.62%, P=0.01).

Conclusions— We conclude that elevated plasma ADMA concentrations are associated with decreased brachial FMD responses in healthy adults. These data provide evidence at the population level that ADMA levels are associated with endothelial function.

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