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(Circulation. 2006;114:645-653.)
© 2006 American Heart Association, Inc.

Imaging

Multislice Spiral Computed Tomography for the Evaluation of Stent Patency After Left Main Coronary Artery Stenting

A Comparison With Conventional Coronary Angiography and Intravascular Ultrasound

Carlos A.G. Van Mieghem, MD; Filippo Cademartiri, MD, PhD; Nico R. Mollet, MD, PhD; Patrizia Malagutti, MD; Marco Valgimigli, MD; Willem B. Meijboom, MD; Francesca Pugliese, MD; Eugene P. McFadden, MB, ChB, FRCPI; Jurgen Ligthart, BSc; Giuseppe Runza, MD; Nico Bruining, PhD; Pieter C. Smits, MD, PhD; Evelyn Regar, MD, PhD; Willem J. van der Giessen, MD, PhD; Georgios Sianos, MD, PhD; Ron van Domburg, PhD; Peter de Jaegere, MD, PhD; Gabriel P. Krestin, MD, PhD; Patrick W. Serruys, MD, PhD; Pim J. de Feyter, MD, PhD

From the Department of Cardiology, Thoraxcenter (C.A.G.V.M., F.C., N.R.M., M.V., W.B.M., E.P.M., J.L., N.B., E.R., W.J.v.d.G., G.S., R.v.D., P.d.J., P.W.S., P.J.d.F.) and Department of Radiology (C.A.G.V.M., F.C., N.R.M., P.M., W.B.M., F.P., G.R., G.P.K., P.J.d.F.), Erasmus MC, Rotterdam, the Netherlands; and Medical Center Rijnmond Zuid (P.C.S.), Rotterdam, the Netherlands.

Correspondence to Pim J. de Feyter, MD, PhD, Erasmus MC, Ba 589, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands. E-mail p.j.defeyter{at}erasmusmc.nl

Received December 17, 2005; revision received June 7, 2006; accepted June 8, 2006.

Background— Surveillance conventional coronary angiography (CCA) is recommended 2 to 6 months after stent-supported left main coronary artery (LMCA) percutaneous coronary intervention due to the unpredictable occurrence of in-stent restenosis (ISR), with its attendant risks. Multislice computed tomography (MSCT) is a promising technique for noninvasive coronary evaluation. We evaluated the diagnostic performance of high-resolution MSCT to detect ISR after stenting of the LMCA.

Methods and Results— Seventy-four patients were prospectively identified from a consecutive patient population scheduled for follow-up CCA after LMCA stenting and underwent MSCT before CCA. Until August 2004, a 16-slice scanner was used (n=27), but we switched to the 64-slice scanner after that period (n=43). Patients with initial heart rates >65 bpm received ß-blockers, which resulted in a mean periscan heart rate of 57±7 bpm. Among patients with technically adequate scans (n=70), MSCT correctly identified all patients with ISR (10 of 70) but misclassified 5 patients without ISR (false-positives). Overall, the accuracy of MSCT for detection of angiographic ISR was 93%. The sensitivity, specificity, and positive and negative predictive values were 100%, 91%, 67%, and 100%, respectively. When analysis was restricted to patients with stenting of the LMCA with or without extension into a single major side branch, accuracy was 98%. When both branches of the LMCA bifurcation were stented, accuracy was 83%. For the assessment of stent diameter and area, MSCT showed good correlation with intravascular ultrasound (r=0.78 and 0.73, respectively). An intravascular ultrasound threshold value 1 mm was identified to reliably detect in-stent neointima hyperplasia with MSCT.

Conclusions— Current MSCT technology, in combination with optimal heart rate control, allows reliable noninvasive evaluation of selected patients after LMCA stenting. MSCT is safe to exclude left main ISR and may therefore be an acceptable first-line alternative to CCA.

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