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(Circulation. 2006;114:289-297.)
© 2006 American Heart Association, Inc.

Epidemiology

Lower Myocardial Perfusion Reserve Is Associated With Decreased Regional Left Ventricular Function in Asymptomatic Participants of the Multi-Ethnic Study of Atherosclerosis

Boaz D. Rosen, MD; João A.C. Lima, MD; Khurram Nasir, MD, MPH; Thor Edvardsen, MD, PhD; Aaron R. Folsom, MD, MPH; Shenghan Lai, MD, PhD; David A. Bluemke, MD, PhD; Michael Jerosch-Herold, PhD

From the Cardiology Division of the Department of Medicine (B.D.R., J.A.C.L., K.N., T.E.), the Department of Radiology (D.A.B., J.A.C.L.), the Department of Epidemiology, and the Bloomberg School of Public Health and Hygiene (S.L.), Johns Hopkins University, Baltimore, Md; and the University of Minnesota, Minneapolis (A.R.F., M.J.H.).

Correspondence to Dr Michael Jerosch-Herold, Advanced Imaging Research Center, Oregon Health and Science University, Mail Code L452, 3181 SW Sam Jackson Park Road, Portland, OR 97239. E-mail jeroschh{at}ohsu.edu

Received April 18, 2005; de novo received September 13, 2005; revision received May 12, 2006; accepted May 16, 2006.

Background— Myocardial ischemia is an important determinant of regional left ventricular systolic function. Myocardial blood flow reserve may be impaired by cardiovascular disease before alterations of myocardial perfusion at rest become manifest. Nevertheless, the relation between flow reserve and regional myocardial function has not been studied in individuals without a history of clinical heart disease.

Methods and Results— Seventy-four participants (66±9 years, mean±SD) of the Multi-Ethnic Study of Atherosclerosis (MESA) underwent myocardial magnetic resonance tagging and contrast-enhanced perfusion studies. Regional myocardial function was evaluated as peak systolic circumferential strain (Ecc) in the three main coronary territories (left anterior descending [LAD], left circumflex, and right coronary artery [RCA]). Myocardial blood flow at rest and during adenosine-induced hyperemia was quantified by contrast-enhanced magnetic resonance imaging, to study the relation between regional flow and function after multivariable adjustment for age, gender, body mass index, left ventricular mass, and traditional risk factors. Lower regional myocardial blood flow during hyperemia was associated with reduced regional left ventricular function expressed as lower Ecc in the RCA (P<0.01) and left circumflex regions (P<0.05) measured in the subendocardium, mid-wall, and subepicardium. In contrast, no significant association was seen in the LAD territory (P=0.16). In addition, segmental function in LAD and RCA regions was reduced when individuals in the lowest 10th percentile for regional myocardial flow reserve were compared with the other participants. Absolute decreases in mid-wall Ecc LAD and RCA and global Ecc were 3.0%, 3.4%, and 2.8%, respectively (P<0.05 for all regions).

Conclusions— Lower myocardial flow reserve is related to reduced regional function in asymptomatic individuals.

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