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Circulation. 2006;113:842-850
Published online before print February 6, 2006, doi: 10.1161/CIRCULATIONAHA.105.582882
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Right arrow Valvular heart disease
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(Circulation. 2006;113:842-850.)
© 2006 American Heart Association, Inc.


Valvular Heart Disease

Percutaneous Aortic Valve Implantation Retrograde From the Femoral Artery

John G. Webb, MD; Mann Chandavimol, MD; Christopher R. Thompson, MD; Donald R. Ricci, MD; Ronald G. Carere, MD; Brad I. Munt; Christopher E. Buller, MD; Sanjeevan Pasupati, MD; Samuel Lichtenstein, MD

From the Divisions of Cardiology and Cardiac Surgery, St. Paul’s Hospital, Vancouver, British Columbia, Canada.

Correspondence to John G. Webb, MD, Director, Interventional Cardiology, St. Paul’s Hospital, Room 5202A, 1081 Burrard St, Vancouver, British Columbia, Canada V6Z 1Y6. E-mail webb{at}providencehealth.bc.ca

Received August 11, 2005; revision received September 26, 2005; accepted October 21, 2005.

Background— Percutaneous aortic valve implantation by an antegrade transvenous approach has been described but is problematic. Retrograde prosthetic aortic valve implantation via the femoral artery has potential advantages. Percutaneous prosthetic aortic valve implantation via the femoral arterial approach is described and the initial experience reported.

Methods and Results— The valve prosthesis is constructed from a stainless steel stent with an attached trileaflet equine pericardial valve and a fabric cuff. After routine aortic balloon valvuloplasty, a 22F or 24F sheath is advanced from the femoral artery to the aorta. A steerable, deflectable catheter facilitates manipulation of the prosthesis around the aortic arch and through the stenotic valve. Rapid ventricular pacing is used to reduce cardiac output while the delivery balloon is inflated to deploy the prosthesis within the annulus. Percutaneous aortic prosthetic valve implantation was attempted in 18 patients (aged 81±6 years) in whom surgical risk was deemed excessive because of comorbidities. Iliac arterial injury, seen in the first 2 patients, did not recur after improvement in screening and access site management. Implantation was successful in 14 patients. After successful implantation, the aortic valve area increased from 0.6±0.2 to 1.6±0.4 cm2. There were no intraprocedural deaths. At follow-up of 75±55 days, 16 patients (89%) remained alive.

Conclusions— This initial experience suggests that percutaneous transarterial aortic valve implantation is feasible in selected high-risk patients with satisfactory short-term outcomes.


Key Words: aorta • stenosis • catheters • stents • valvuloplasty




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J. Am. Coll. Cardiol. Img., January 1, 2008; 1(1): 15 - 24.
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W. J. Stewart
Imaging the future of transcatheter aortic valve replacement.
J. Am. Coll. Cardiol. Img., January 1, 2008; 1(1): 25 - 28.
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T. M. Dewey, D. Brown, W. H. Ryan, M. A. Herbert, S. L. Prince, and M. J. Mack
Reliability of risk algorithms in predicting early and late operative outcomes in high-risk patients undergoing aortic valve replacement
J. Thorac. Cardiovasc. Surg., January 1, 2008; 135(1): 180 - 187.
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M. J. Davidson and D. S. Baim
Percutaneous Aortic Valve Interventions
Card. Surg. Adult, January 1, 2008; 3(2008): 963 - 971.
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CirculationHome page
T. Feldman and M. B. Leon
Prospects for Percutaneous Valve Therapies
Circulation, December 11, 2007; 116(24): 2866 - 2877.
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E. Berreklouw, B. Vogel, H. Fischer, F. Weinberg, G. L. van Rijk-Zwikker, G. J. Van Nooten, and L. H. Cohn
Fast sutureless implantation of mechanical aortic valve prostheses using Nitinol attachment rings: Feasibility in acute pig experiments.
J. Thorac. Cardiovasc. Surg., December 1, 2007; 134(6): 1508 - 1512.
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B. Marcheix, Y. Lamarche, C. Berry, A. Asgar, J.-C. Laborde, A. Basmadjian, A. Ducharme, A. Denault, R. Bonan, and R. Cartier
Surgical aspects of endovascular retrograde implantation of the aortic CoreValve bioprosthesis in high-risk older patients with severe symptomatic aortic stenosis.
J. Thorac. Cardiovasc. Surg., November 1, 2007; 134(5): 1150 - 1156.
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S. H. Goldbarg, S. Elmariah, M. A. Miller, and V. Fuster
Insights Into Degenerative Aortic Valve Disease
J. Am. Coll. Cardiol., September 25, 2007; 50(13): 1205 - 1213.
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J. G. Webb, S. Pasupati, K. Humphries, C. Thompson, L. Altwegg, R. Moss, A. Sinhal, R. G. Carere, B. Munt, D. Ricci, et al.
Percutaneous Transarterial Aortic Valve Replacement in Selected High-Risk Patients With Aortic Stenosis
Circulation, August 14, 2007; 116(7): 755 - 763.
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E. M. Flecher, J. W. Curry, T. M. Joudinaud, C. L. Kegel, P. A. Weber, and C. M.G. Duran
Coronary flow obstruction in percutaneous aortic valve replacement. An in vitro study
Eur. J. Cardiothorac. Surg., August 1, 2007; 32(2): 291 - 294.
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S. R. Dixon, C. L. Grines, and W. W. O'Neill
The Year in Interventional Cardiology
J. Am. Coll. Cardiol., July 17, 2007; 50(3): 270 - 285.
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E. Grube, G. Schuler, L. Buellesfeld, U. Gerckens, A. Linke, P. Wenaweser, B. Sauren, F.-W. Mohr, T. Walther, B. Zickmann, et al.
Percutaneous Aortic Valve Replacement for Severe Aortic Stenosis in High-Risk Patients Using the Second- and Current Third-Generation Self-Expanding CoreValve Prosthesis: Device Success and 30-Day Clinical Outcome
J. Am. Coll. Cardiol., July 3, 2007; 50(1): 69 - 76.
[Abstract] [Full Text] [PDF]


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CirculationHome page
J. Bergler-Klein, G. Mundigler, P. Pibarot, I. G. Burwash, J. G. Dumesnil, C. Blais, C. Fuchs, D. Mohty, R. S. Beanlands, Z. Hachicha, et al.
B-Type Natriuretic Peptide in Low-Flow, Low-Gradient Aortic Stenosis: Relationship to Hemodynamics and Clinical Outcome: Results From the Multicenter Truly or Pseudo-Severe Aortic Stenosis (TOPAS) Study
Circulation, June 5, 2007; 115(22): 2848 - 2855.
[Abstract] [Full Text] [PDF]


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L. Coats and P. Bonhoeffer
NEW PERCUTANEOUS TREATMENTS FOR VALVE DISEASE
Heart, May 1, 2007; 93(5): 639 - 644.
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J. Ye, A. Cheung, S. V. Lichtenstein, S. Pasupati, R. G. Carere, C. R. Thompson, A. Sinhal, and J. G. Webb
Six-month outcome of transapical transcatheter aortic valve implantation in the initial seven patients
Eur. J. Cardiothorac. Surg., January 1, 2007; 31(1): 16 - 21.
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Y. Lamarche, R. Cartier, A. Y. Denault, A. Basmadjian, C. Berry, J.-C. Laborde, and R. Bonan
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Ann. Thorac. Surg., January 1, 2007; 83(1): 284 - 287.
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E. Grube, J. C. Laborde, U. Gerckens, T. Felderhoff, B. Sauren, L. Buellesfeld, R. Mueller, M. Menichelli, T. Schmidt, B. Zickmann, et al.
Percutaneous Implantation of the CoreValve Self-Expanding Valve Prosthesis in High-Risk Patients With Aortic Valve Disease: The Siegburg First-in-Man Study
Circulation, October 10, 2006; 114(15): 1616 - 1624.
[Abstract] [Full Text] [PDF]


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B Munt and J Webb
Percutaneous valve repair and replacement techniques
Heart, October 1, 2006; 92(10): 1369 - 1372.
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J. D. Carroll
The Evolving Treatment of Aortic Stenosis: Do New Procedures Provide New Treatment Options for the Highest-Risk Patients?
Circulation, August 8, 2006; 114(6): 533 - 535.
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S. V. Lichtenstein, A. Cheung, J. Ye, C. R. Thompson, R. G. Carere, S. Pasupati, and J. G. Webb
Transapical Transcatheter Aortic Valve Implantation in Humans: Initial Clinical Experience
Circulation, August 8, 2006; 114(6): 591 - 596.
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S. V. Lichtenstein
Closed heart surgery: Back to the future
J. Thorac. Cardiovasc. Surg., May 1, 2006; 131(5): 941 - 943.
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J. Ye, A. Cheung, S. V. Lichtenstein, R. G. Carere, C. R. Thompson, S. Pasupati, and J. G. Webb
Transapical aortic valve implantation in humans
J. Thorac. Cardiovasc. Surg., May 1, 2006; 131(5): 1194 - 1196.
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Percutaneous Treatment of Valvular Heart Disease
Journal Watch Cardiology, March 23, 2006; 2006(323): 3 - 3.
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T. Feldman
Percutaneous Valve Repair and Replacement: Challenges Encountered, Challenges Met, Challenges Ahead
Circulation, February 14, 2006; 113(6): 771 - 773.
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CirculationHome page
R. J. Shemin
Percutaneous Valve Intervention: A Surgeon's Perspective
Circulation, February 14, 2006; 113(6): 774 - 775.
[Full Text] [PDF]