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(Circulation. 2006;113:2406-2412.)
© 2006 American Heart Association, Inc.

Interventional Cardiology

Impact of Completeness of Percutaneous Coronary Intervention Revascularization on Long-Term Outcomes in the Stent Era

Edward L. Hannan, PhD; Michael Racz, PhD; David R. Holmes, MD; Spencer B. King, III, MD; Gary Walford, MD; John A. Ambrose, MD; Samin Sharma, MD; Stanley Katz, MD; Luther T. Clark, MD; Robert H. Jones, MD

From the State University of New York, University at Albany (E.L.H.); New York State Department of Health, Albany (M.R.); Mayo Clinic, Rochester, Minn (D.R.H.); Fuqua Heart Center/Piedmont Hospital, Atlanta, Ga (S.B.K.); St Joseph’s Hospital, Syracuse, NY (G.W.); University of California at San Francisco School of Medicine, Fresno (J.A.A.); Mt Sinai Medical Center, New York, NY (S.S.); North Shore–Long Island Jewish Health System, Manhasset, NY (S.K.); University Hospital of Brooklyn, Brooklyn, NY (L.T.C.); and Duke University Medical Center, Durham, NC (R.H.J.).

Correspondence to Edward L. Hannan, PhD, School of Public Health, State University of New York, University at Albany, One University Place, Rensselaer, NY 12144-3456. E-mail elh03{at}health.state.ny.us

Received January 6, 2006; revision received January 6, 2006; accepted February 24, 2006.

Background— The importance of completeness of revascularization by percutaneous coronary intervention in patients with multivessel disease is unclear in that there is little information on the impact of incomplete revascularization outside of randomized trials. The objective of this study is to compare long-term mortality and subsequent revascularization for percutaneous coronary intervention patients receiving stents who were completely revascularized (CR) with those who were incompletely revascularized (IR).

Methods and Results— Patients from New York State’s Percutaneous Coronary Interventions Reporting System were subdivided into patients who were CR and IR. Then subsets of IR patients were contrasted with CR patients. Differences in long-term survival and subsequent revascularization for CR and IR patients were compared after adjustment for differences in preprocedural risk. A total of 68.9% of all stent patients with multivessel disease who were studied were IR, and 30.1% of all patients had total occlusions and/or 2 IR vessels. At baseline, the following patients were at higher risk: those who were older and those with more comorbid conditions, worse ejection fraction, and more renal disease and stroke. After adjustment for these baseline differences, IR patients were significantly more likely to die at any time (adjusted hazard ratio=1.15; 95% confidence interval, 1.01 to 1.30) than CR patients. IR patients with total occlusions and a total of 2 IR vessels were at the highest risk compared with CR patients (hazard ratio=1.36; 95% confidence interval, 1.12 to 1.66).

Conclusions— IR with stenting is associated with an adverse impact on long-term mortality, and consideration should be given to either achieving CR, opting for surgery, or monitoring percutaneous coronary intervention patients with IR more closely after discharge.

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