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(Circulation. 2006;113:2113-2119.)
© 2006 American Heart Association, Inc.

Valvular Heart Disease

Features of the Metabolic Syndrome and Diabetes Mellitus as Predictors of Aortic Valve Calcification in the Multi-Ethnic Study of Atherosclerosis

Ronit Katz, PhD; Nathan D. Wong, PhD; Richard Kronmal, PhD; Junichiro Takasu, MD, PhD; David M. Shavelle, MD; Jeffrey L. Probstfield, MD; Alain G. Bertoni, MD, MPH; Matthew J. Budoff, MD; Kevin D. O’Brien, MD

From the University of Washington (R. Katz, R. Kronmal, J.L.P., K.D.O.), Seattle, Wash; University of California (N.D.W.), Irvine, Calif; Harbor-UCLA Research and Education Institute (J.T., D.M.S., M.J.B.), Torrance, Calif; and Wake Forest University Health Sciences (A.G.B.), Winston-Salem, NC.

Correspondence to Kevin D. O’Brien, MD, Division of Cardiology, Box 354622, University of Washington, 1959 NE Pacific St, Seattle, WA

Received November 8, 2005; revision received February 9, 2006; accepted February 24, 2006.

Background— Calcific aortic valve disease is common in the elderly, is correlated with common cardiovascular risk factors, and is associated with increased cardiovascular event risk; however, whether metabolic syndrome is associated with an increased prevalence of aortic valve calcium (AVC) is not known.

Methods and Results— The prevalence of AVC, as assessed by computed tomography, was compared in 6780 Multi-Ethnic Study of Atherosclerosis (MESA) participants with metabolic syndrome (n=1550; National Cholesterol Education Program’s Adult Treatment Panel III [ATP III] criteria), diabetes mellitus (n=1016), or neither condition (n=4024). The prevalence of AVC for those with neither condition, metabolic syndrome, or diabetes mellitus was, respectively, 8%, 12%, and 17% in women (P<0.001) and 14%, 22%, and 24% in men (P<0.001). Compared with those with neither condition, the adjusted relative risks for the presence of AVC were 1.45 (95% CI 1.11 to 1.90) for metabolic syndrome and 2.12 (95% CI 1.54 to 2.92) for diabetes mellitus in women and 1.70 (95% CI 1.32 to 2.19) for metabolic syndrome and 1.73 (95% CI 1.33 to 2.25) for diabetes mellitus in men. There was a graded, linear relationship between AVC prevalence and the number of metabolic syndrome components in both women and men (both P<0.001). Similar results were obtained when the International Diabetes Federation metabolic syndrome definition was used.

Conclusions— In the MESA cohort, the metabolic syndrome and diabetes mellitus are associated with increased risk of AVC, and AVC prevalence is increased with increasing number of metabolic syndrome components.

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