This Article Free upon publication Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fries, R. Articles by Böhm, M. Search for Related Content PubMed PubMed Citation Articles by Fries, R. Articles by Böhm, M. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information Raynaud's Disease Related Collections Endothelium/vascular type/nitric oxide Other Treatment

(Circulation. 2005;112:2980-2985.)
© 2005 American Heart Association, Inc.

Vascular Medicine

Sildenafil in the Treatment of Raynaud’s Phenomenon Resistant to Vasodilatory Therapy

Roland Fries, MD; Kaveh Shariat, MD; Hubertus von Wilmowsky, MD; Michael Böhm, MD

From Klinik für Innere Medizin III (Kardiologie, Angiologie, Internistische Intensivmedizin), Universitätsklinikum des Saarlandes, Homburg/Saar (R.F., K.S., M.B.), and Klinik für Rheumatologie, Knappschaftskrankenhaus, Püttlingen (H.v.W.), Germany.

Correspondence to Priv-Doz Dr Roland Fries, Gotthard-Schettler-Klinik, Prof-Kurt-Sauer Str 4, 76669 Bad Schönborn, Germany. (E-mail r.fries{at}gotthard-schettler-klinik.de), or to Prof Dr M. Böhm, Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, 66421 Homburg/Saar, Germany (E-mail michael.boehm@uniklinikum-saarland.de).

Received November 23, 2004; revision received June 14, 2005; accepted July 12, 2005.

Background— Vasodilatory therapy of Raynaud’s phenomenon represents a difficult clinical problem because treatment often remains inefficient and may be not tolerated because of side effects.

Methods and Results— To investigate the effects of sildenafil on symptoms and capillary perfusion in patients with Raynaud’s phenomenon, we performed a double-blinded, placebo-controlled, fixed-dose, crossover study in 16 patients with symptomatic secondary Raynaud’s phenomenon resistant to vasodilatory therapy. Patients were treated with 50 mg sildenafil or placebo twice daily for 4 weeks. Symptoms were assessed by diary cards including a 10-point Raynaud’s Condition Score. Capillary flow velocity was measured in digital nailfold capillaries by means of a laser Doppler anemometer. While taking sildenafil, the mean frequency of Raynaud attacks was significantly lower (35±14 versus 52±18, P=0.0064), the cumulative attack duration was significantly shorter (581±133 versus 1046±245 minutes, P=0.0038), and the mean Raynaud’s Condition Score was significantly lower (2.2±0.4 versus 3.0±0.5, P=0.0386). Capillary blood flow velocity increased in each individual patient, and the mean capillary flow velocity of all patients more than quadrupled after treatment with sildenafil (0.53±0.09 versus 0.13±0.02 mm/s, P=0.0004). Two patients reported side effects leading to discontinuation of the study drug.

Conclusions— Sildenafil is an effective and well-tolerated treatment in patients with Raynaud’s phenomenon.

Key Words: microcirculation • capillaries • drugs • blood flow • nitric oxide

This article has been cited by other articles:

				D Khanna, D J Lovell, E Giannini, P J Clements, P A Merkel, J R Seibold, M Matucci-Cerinic, C P Denton, M D Mayes, V D Steen, et al. Development of a provisional core set of response measures for clinical trials of systemic sclerosis Ann Rheum Dis, May 1, 2008; 67(5): 703 - 709. [Abstract] [Full Text] [PDF]

				S. C. Moore and E. R. H. DeSantis Treatment of complications associated with systemic sclerosis Am. J. Health Syst. Pharm., February 15, 2008; 65(4): 315 - 321. [Abstract] [Full Text] [PDF]

				U. Wollina, M. Buslau, B. Heinig, I. Petrov, E. Unger, E. Kyriopoulou, A. Koch, E. Kostler, J. Schonlebe, G. Haroske, et al. Disabling Pansclerotic Morphea of Childhood Poses a High Risk of Chronic Ulceration of the Skin and Squamous Cell Carcinoma International Journal of Lower Extremity Wounds, December 1, 2007; 6(4): 291 - 298. [Abstract] [PDF]

				Sildenafil for Raynaud's Journal Watch (General), October 3, 2006; 2006(1003): 8 - 8. [Full Text]

				G. Riemekasten and C. Sunderkotter Vasoactive therapies in systemic sclerosis Rheumatology, October 1, 2006; 45(suppl_3): iii49 - iii51. [Abstract] [Full Text] [PDF]

				T. L Levien Phosphodiesterase Inhibitors in Raynaud's Phenomenon Ann. Pharmacother., July 1, 2006; 40(7): 1388 - 1393. [Abstract] [Full Text] [PDF]

				Other articles noted Evid. Based Med., April 1, 2006; 11(2): 63 - 64. [Full Text] [PDF]

				F. Mahler and I. Baumgartner More Potential for Sildenafil Than Potency Circulation, November 8, 2005; 112(19): 2894 - 2895. [Full Text] [PDF]