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(Circulation. 2005;111:3158-3166.)
© 2005 American Heart Association, Inc.

Special Report

Report of the National Heart, Lung, and Blood Institute Working Group on Outcomes Research in Cardiovascular Disease

Harlan M. Krumholz, MD, SM (Chair); Eric D. Peterson, MD, MPH (Cochair); John Z. Ayanian, MD, MPP; Marshall H. Chin, MD, MPH; Robert F. DeBusk, MD; Lee Goldman, MD, MPH; Catarina I. Kiefe, PhD, MD; Neil R. Powe, MD, MPH, MBA; John S. Rumsfeld, MD, PhD; John A. Spertus, MD, MPH; William S. Weintraub, MD

From the Departments of Medicine and of Epidemiology and Public Health (H.M.K.), Yale University School of Medicine and Yale-New Haven Health Center for Outcomes Research and Evaluation, New Haven, Conn; Duke University Medical Center and Duke Clinical Research Institute (E.D.P.), Durham, NC; Department of Medicine (J.Z.A.), Brigham and Women’s Hospital and Harvard Medical School, and the Department of Health Care Policy, Harvard Medical School, Boston, Mass; Department of Medicine (M.E.C.), Diabetes Research and Training Center, University of Chicago, Chicago, Ill; Stanford Cardiac Rehabilitation Program (R.F.D.), Stanford University School of Medicine, Stanford, Calif; Department of Medicine (L.G.), University of California, San Francisco; Department of Medicine (C.I.K.), University of Alabama at Birmingham; Welch Center for Prevention, Epidemiology, and Clinical Research (N.R.P.), Johns Hopkins Medical Institutions, Baltimore, Md; Cardiology and Health Services Research (J.S.R.), Denver Veterans Administration Medical Center, University of Colorado Health Sciences Center, Denver; University of Missouri and Mid-America Heart Institute of Saint Luke’s Hospital (J.A.S.), Kansas City, Mo; and Emory Center for Outcomes Research (W.S.W.), Emory University, Atlanta, Ga.

Correspondence to Dr Harlan M. Krumholz, Yale University School of Medicine, P.O. Box 208088, New Haven, CT 06520-8088. E-mail harlan.krumholz{at}yale.edu

Received January 14, 2005; revision received March 25, 2005; accepted March 31, 2005.

The National Heart, Lung, and Blood Institute convened a working group on outcomes research in cardiovascular disease (CVD). The working group sought to provide guidance on research priorities in outcomes research related to CVD. For the purposes of this document, "outcomes research" is defined as investigative endeavors that generate knowledge to improve clinical decision making and healthcare delivery to optimize patient outcomes. The working group identified the following priority areas: (1) national surveillance projects for high-prevalence CV conditions; (2) patient-centered care; (3) translation of the best science into clinical practice; and (4) studies that place the cost of interventions in the context of their real-world effectiveness. Within each of these topics, the working group described examples of initiatives that could serve the Institute and the public. In addition, the group identified the following areas that are important to the field: (1) promotion of the use of existing data; (2) facilitation of collaborations with other federal agencies; (3) investigations into the basic science of outcomes research, with an emphasis on methodological advances; (4) strengthening of appropriate study sections with individuals who have expertise in outcomes research; and (5) expansion of opportunities to train new outcomes research investigators. The working group concluded that a dedicated investment in CV outcomes research could directly improve the care delivered in the United States.

Key Words: outcome assessment • cardiovascular diseases • patients • statistics

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