This Article Full Text Full Text (PDF) All Versions of this Article: 110/24/3715    most recent 01.CIR.0000149747.82157.01v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Yang, Z. Articles by Ballinger, S. W. Search for Related Content PubMed PubMed Citation Articles by Yang, Z. Articles by Ballinger, S. W. Pubmed/NCBI databases Substance via MeSH Medline Plus Health Information Dietary Fats High Risk Pregnancy Secondhand Smoke Related Collections Animal models of human disease Pathophysiology Risk Factors Oxidant stress

(Circulation. 2004;110:3715-3720.)
© 2004 American Heart Association, Inc.

Vascular Medicine

Prenatal Environmental Tobacco Smoke Exposure Promotes Adult Atherogenesis and Mitochondrial Damage in Apolipoprotein E^–/– Mice Fed a Chow Diet

Zhen Yang, MD; Cynthia A. Knight, BS; Madonna M. Mamerow, MS; Kasey Vickers, BS; Arthur Penn, PhD; Edward M. Postlethwait, PhD; Scott W. Ballinger, PhD

From the Division of Molecular and Cellular Pathology, Department of Pathology (Z.Y., C.A.K., K.V., S.W.B.), and Department of Environmental Health Sciences, School of Public Health (E.M.P.), University of Alabama at Birmingham; Department of Human Ecology, Division of Nutritional Sciences, University of Texas at Austin (M.M.M.); and School of Veterinary Medicine, Louisiana State University, Baton Rouge (A.P.).

Correspondence to Scott W. Ballinger, PhD, Division of Molecular and Cellular Pathology, VH G019F, 1530 3rd Ave S, Birmingham, AL 35294-0019. E-mail sballing{at}path.uab.edu

Received May 19, 2004; revision received August 12, 2004; accepted September 9, 2004.

Background— Environmental tobacco smoke (ETS) exposure is recognized as a cardiovascular disease risk factor; however, the impact of prenatal ETS exposure on adult atherogenesis has not been examined. We hypothesized that in utero ETS exposure promotes adult atherosclerotic lesion formation and mitochondrial damage.

Methods and Results— Atherosclerotic lesion formation, mitochondrial DNA damage, antioxidant activity, and oxidant load were determined in cardiovascular tissues from adult apolipoprotein E^–/– mice exposed to either filtered air or ETS in utero and fed a standard chow diet (4.5% fat) from weaning until euthanasia. All parameters were significantly altered in male mice exposed in utero to ETS.

Conclusions— These data support the hypothesis that prenatal ETS exposure is sufficient to promote adult cardiovascular disease development.

Key Words: smoking • mitochondria • pregnancy • prenatal exposure delayed effects • atherosclerosis

This article has been cited by other articles:

				W. Palinski Sodium Exposure Induces Stroke in a Genetically Susceptible Model: New Insights Into Early-Life Factors Modulating Adult Disease Circulation, March 24, 2009; 119(11): 1459 - 1462. [Full Text] [PDF]

				M. Miller, J. Y. Cho, A. Pham, J. Ramsdell, and D. H. Broide Adiponectin and Functional Adiponectin Receptor 1 Are Expressed by Airway Epithelial Cells in Chronic Obstructive Pulmonary Disease J. Immunol., January 1, 2009; 182(1): 684 - 691. [Abstract] [Full Text] [PDF]

				W. Palinski and C. Napoli Impaired Fetal Growth, Cardiovascular Disease, and the Need to Move on Circulation, January 22, 2008; 117(3): 341 - 343. [Full Text] [PDF]

				M. G. Min, D. J. Song, M. Miller, J. Y. Cho, S. McElwain, P. Ferguson, and D. H. Broide Coexposure to Environmental Tobacco Smoke Increases Levels of Allergen-Induced Airway Remodeling in Mice J. Immunol., April 15, 2007; 178(8): 5321 - 5328. [Abstract] [Full Text] [PDF]

				N. R. Madamanchi and M. S. Runge Mitochondrial Dysfunction in Atherosclerosis Circ. Res., March 2, 2007; 100(4): 460 - 473. [Abstract] [Full Text] [PDF]

				I. Basyigit, M. Tugay, M.O. Dilioglugil, F. Yildiz, H. Maral, and S. Sozubir Protective effects of N-acetylcysteine on peroxidative changes of the fetal rat lungs whose mothers were exposed to cigarette smoke Human and Experimental Toxicology, February 1, 2007; 26(2): 99 - 103. [Abstract] [PDF]

				J. Gutierrez, S. W. Ballinger, V. M. Darley-Usmar, and A. Landar Free Radicals, Mitochondria, and Oxidized Lipids: The Emerging Role in Signal Transduction in Vascular Cells Circ. Res., October 27, 2006; 99(9): 924 - 932. [Abstract] [Full Text] [PDF]

				T. Raupach, K. Schafer, S. Konstantinides, and S. Andreas Secondhand smoke as an acute threat for the cardiovascular system: a change in paradigm Eur. Heart J., February 2, 2006; 27(4): 386 - 392. [Abstract] [Full Text] [PDF]

				S. P. Ng, A. E. Silverstone, Z.-W. Lai, and J. T. Zelikoff Effects of Prenatal Exposure to Cigarette Smoke on Offspring Tumor Susceptibility and Associated Immune Mechanisms Toxicol. Sci., January 1, 2006; 89(1): 135 - 144. [Abstract] [Full Text] [PDF]