This Article Full Text Full Text (PDF) All Versions of this Article: 110/23/3599    most recent 01.CIR.0000148820.55611.6Bv1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ferreira, A. C. Articles by de Marchena, E. Search for Related Content PubMed PubMed Citation Articles by Ferreira, A. C. Articles by de Marchena, E. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information Dietary Fats Triglycerides Related Collections Nutrition Lipids Lipid and lipoprotein metabolism Endothelium/vascular type/nitric oxide Mechanism of atherosclerosis/growth factors Other Vascular biology Other diagnostic testing

(Circulation. 2004;110:3599-3603.)
© 2004 American Heart Association, Inc.

Vascular Medicine

Postprandial Hypertriglyceridemia Increases Circulating Levels of Endothelial Cell Microparticles

Alexandre C. Ferreira, MD; Arley A. Peter, MD; Armando J. Mendez, PhD; Joaquín J. Jimenez, MD; Lucia M. Mauro; Julio A. Chirinos, MD; Reyan Ghany, MD; Salim Virani, MD; Santiago Garcia, MD; Lawrence L. Horstman; Joshua Purow, MD; Wenche Jy, PhD; Yeon S. Ahn, MD; Eduardo de Marchena, MD

From the University of Miami School of Medicine, Cardiovascular Center (A.C.F., A.A.P., J.A.C., R.G., S.V., S.G., L.L.H., J.P., E.D.M.), Diabetes Research Institute (A.J.M.), and Wallace H. Coulter Platelet Laboratory (J.J.J., L.M.M., W.J., Y.S.A.), Miami, Fla.

Correspondence to Alexandre Ferreira, MD, Director, Coronary Care Unit, Department of Medicine, Division of Cardiology, PO Box 016960, Miami, FL 33101. E-mail aferreir{at}med.miami.edu

Received April 15, 2004; revision received August 3, 2004; accepted August 12, 2004.

Background— This study evaluated a possible relationship between levels of endothelial microparticles (EMPs), known to be a sensitive indicator of endothelial disturbance, and changes in postprandial lipid levels in healthy volunteers after a low- or high-fat meal.

Methods and Results— Eighteen healthy subjects without known cardiovascular risk factors were evaluated. Lipid and EMP levels were measured before and 1 and 3 hours after a single low- or high-fat isocaloric meal. The low-fat meal had no significant postprandial effect on EMPs or lipids compared with fasting levels. In contrast, a single high-fat meal significantly increased EMP levels after 1 and 3 hours, from 389±54 (thousands per milliliter) when fasting to 541±139 (P=0.0002) and 677±159 (P<0.0001), respectively, and correlated with a postprandial elevation in serum triglycerides.

Conclusions— A single high-fat meal led to a significant elevation of plasma EMP levels in healthy, normolipidemic subjects and correlated with a postprandial elevation of serum triglycerides. EMPs may be an indirect marker of endothelial dysfunction or injury induced by postprandial triglyceride-rich lipoproteins.

Key Words: hypertriglyceridemia • endothelium • microparticles

This article has been cited by other articles:

				F. Mariotti, J. F. Huneau, I. Szezepanski, K. J. Petzke, Y. Aggoun, D. Tome, and D. Bonnet Meal Amino Acids with Varied Levels of Arginine do Not Affect Postprandial Vascular Endothelial Function in Healthy Young Men J. Nutr., June 1, 2007; 137(6): 1383 - 1389. [Abstract] [Full Text] [PDF]

				M. E. Tushuizen, R. Nieuwland, C. Rustemeijer, B. E. Hensgens, A. Sturk, R. J. Heine, and M. Diamant Elevated Endothelial Microparticles Following Consecutive Meals Are Associated With Vascular Endothelial Dysfunction in Type 2 Diabetes Diabetes Care, March 1, 2007; 30(3): 728 - 730. [Full Text] [PDF]

				O. Morel, F. Toti, B. Hugel, B. Bakouboula, L. Camoin-Jau, F. Dignat-George, and J.-M. Freyssinet Procoagulant Microparticles: Disrupting the Vascular Homeostasis Equation? Arterioscler. Thromb. Vasc. Biol., December 1, 2006; 26(12): 2594 - 2604. [Abstract] [Full Text] [PDF]

				G. Chironi, A. Simon, B. Hugel, M. Del Pino, J. Gariepy, J.-M. Freyssinet, and A. Tedgui Circulating Leukocyte-Derived Microparticles Predict Subclinical Atherosclerosis Burden in Asymptomatic Subjects Arterioscler. Thromb. Vasc. Biol., December 1, 2006; 26(12): 2775 - 2780. [Abstract] [Full Text] [PDF]

				K. Esposito, M. Ciotola, B. Schisano, R. Gualdiero, L. Sardelli, L. Misso, G. Giannetti, and D. Giugliano Endothelial Microparticles Correlate with Endothelial Dysfunction in Obese Women J. Clin. Endocrinol. Metab., September 1, 2006; 91(9): 3676 - 3679. [Abstract] [Full Text] [PDF]

				C. M. Boulanger, N. Amabile, and A. Tedgui Circulating Microparticles: A Potential Prognostic Marker for Atherosclerotic Vascular Disease Hypertension, August 1, 2006; 48(2): 180 - 186. [Full Text] [PDF]

				D. Giugliano and K. Esposito Virgin Olive Oil and Vegetables Improve Endothelial Health J. Am. Coll. Cardiol., July 18, 2006; 48(2): 413 - 414. [Full Text] [PDF]

				N. Werner, S. Wassmann, P. Ahlers, S. Kosiol, and G. Nickenig Circulating CD31+/Annexin V+ Apoptotic Microparticles Correlate With Coronary Endothelial Function in Patients With Coronary Artery Disease Arterioscler. Thromb. Vasc. Biol., January 1, 2006; 26(1): 112 - 116. [Abstract] [Full Text] [PDF]

				D. Giugliano, R. Marfella, K. Esposito, A. C. Ferreira, A. A. Peter, J. A. Chirinos, R. Ghany, S. Virani, S. Garcia, J. Purow, et al. Letter Regarding Article by Ferriera et al, "Postprandial Hypertriglyceridemia Increases Circulating Levels of Endothelial Cell Microparticles" * Response Circulation, June 28, 2005; 111(25): e457 - e458. [Full Text] [PDF]