This Article Free upon publication Full Text Full Text (PDF) All Versions of this Article: 110/22/3488    most recent 01.CIR.0000149713.48317.27v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Li, X. Articles by Berenson, G. S. Search for Related Content PubMed PubMed Citation Articles by Li, X. Articles by Berenson, G. S. Pubmed/NCBI databases Substance via MeSH Medline Plus Health Information Obesity Obesity in Children Related Collections Epidemiology Related Article

(Circulation. 2004;110:3488-3492.)
© 2004 American Heart Association, Inc.

Preventive Cardiology

Childhood Adiposity as a Predictor of Cardiac Mass in Adulthood

The Bogalusa Heart Study

Xiangrong Li, MD, MSPH; Shengxu Li, MD; Eralp Ulusoy, MD; Wei Chen, MD, PhD; Sathanur R. Srinivasan, PhD; Gerald S. Berenson, MD

From the Tulane Center for Cardiovascular Health, Tulane University Health Sciences Center, New Orleans, La.

Correspondence to Gerald S. Berenson, MD, Tulane Center for Cardiovascular Health, 1440 Canal St, Room 1829, New Orleans, LA 70112. E-mail berenson{at}tulane.edu

Received July 1, 2004; revision received September 3, 2004; accepted September 9, 2004.

Background— The association between left ventricular hypertrophy, an independent predictor of cardiovascular (CV) morbidity and mortality, and CV risk factors has been well documented in childhood and in adulthood. However, information on the relationship between left ventricular mass (LVM) in adults and longitudinal measurements of CV risk factors from childhood to adulthood is limited.

Methods and Results— LVM was obtained with 2D M-mode echocardiography in a community-based sample of 467 young adults (71% white and 29% black) aged 20 to 38 years who were examined an average of 6 times for CV risk factors from childhood to adulthood. The average follow-up period was 21.5 years. The cumulative burden of each risk factor was calculated as the area under the curve for each individual. Compared with whites, blacks had greater LVM (indexed to height^2.7; P<0.05). In multiple regression analyses, adiposity (measured as body mass index) in childhood, adiposity and systolic blood pressure in adulthood, and the cumulative burden of adiposity and systolic blood pressure from childhood to adulthood were significant predictors of LVM index in young adults.

Conclusions— These observations, by showing that adiposity beginning in childhood is a consistent predictor of LVM in young adults, underscore the importance of obesity in the development of left ventricular hypertrophy and the need for early prevention.

Key Words: ventricles • adiposity • blood pressure

Related Article:

Circulation 2004 110: 3399. [Extract] [Full Text]

This article has been cited by other articles:

				J P H Shield, E Crowne, and J Morgan Is there a place for bariatric surgery in treating childhood obesity? Arch. Dis. Child., May 1, 2008; 93(5): 369 - 372. [Full Text] [PDF]

				R. W. Nesto and K. Mackie Endocannabinoid system and its implications for obesity and cardiometabolic risk Eur. Heart J. Suppl., March 1, 2008; 10(suppl_B): B34 - B41. [Abstract] [Full Text] [PDF]

				T. LaFontaine Physical Activity: The Epidemic of Obesity and Overweight Among Youth: Trends, Consequences, and Interventions American Journal of Lifestyle Medicine, February 1, 2008; 2(1): 30 - 36. [Abstract] [PDF]

				F. Mzayek, S. Hassig, R. Sherwin, J. Hughes, W. Chen, S. Srinivasan, and G. Berenson The Association of Birth Weight with Developmental Trends in Blood Pressure from Childhood through Mid-Adulthood: The Bogalusa Heart Study Am. J. Epidemiol., August 15, 2007; 166(4): 413 - 420. [Abstract] [Full Text] [PDF]

				C. Hadtstein and F. Schaefer What adult nephrologists should know about childhood blood pressure Nephrol. Dial. Transplant., August 1, 2007; 22(8): 2119 - 2123. [Full Text] [PDF]

				E. Avelar, T. V. Cloward, J. M. Walker, R. J. Farney, M. Strong, R. C. Pendleton, N. Segerson, T. D. Adams, R. E. Gress, S. C. Hunt, et al. Left Ventricular Hypertrophy in Severe Obesity: Interactions Among Blood Pressure, Nocturnal Hypoxemia, and Body Mass Hypertension, January 1, 2007; 49(1): 34 - 39. [Abstract] [Full Text] [PDF]

				M. Chinali, G. de Simone, M. J. Roman, E. T. Lee, L. G. Best, B. V. Howard, and R. B. Devereux Impact of Obesity on Cardiac Geometry and Function in a Population of Adolescents: The Strong Heart Study J. Am. Coll. Cardiol., June 6, 2006; 47(11): 2267 - 2273. [Abstract] [Full Text] [PDF]

				S. von Haehling, W. Doehner, and S. D. Anker Obesity and the Heart: A Weighty Issue J. Am. Coll. Cardiol., June 6, 2006; 47(11): 2274 - 2276. [Full Text] [PDF]

				M. C. Matteucci, E. Wuhl, S. Picca, A. Mastrostefano, G. Rinelli, C. Romano, G. Rizzoni, O. Mehls, G. de Simone, F. Schaefer, et al. Left Ventricular Geometry in Children with Mild to Moderate Chronic Renal Insufficiency J. Am. Soc. Nephrol., January 1, 2006; 17(1): 218 - 226. [Abstract] [Full Text] [PDF]

				Childhood Adiposity Predicts Adult Hypertrophy DOC News, February 1, 2005; 2(2): 22 - 22. [Full Text]