Circulation. 2004;110:2494-2497
Published online before print October 11, 2004, doi: 10.1161/01.CIR.0000145117.40114.C7
Published online before print October 11, 2004, doi: 10.1161/01.CIR.0000145117.40114.C7
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(Circulation. 2004;110:2494-2497.)
© 2004 American Heart Association, Inc.
Preventive Cardiology |
Prevalence of the Metabolic Syndrome in American Adolescents
Findings From the Third National Health and Nutrition Examination Survey
From the Departments of Cardiology (S.D.d.F., K.G., J.W.N.); Medicine, Divisions of Endocrinology (D.S.L.) and Hematology (E.J.N.); and Laboratory Medicine and Pathology (N.R.), Children’s Hospital, Boston, Mass.
Correspondence to Nader Rifai, PhD, Department of Laboratory Medicine, Children’s Hospital, 300 Longwood Ave, Boston, MA 02115. E-mail nader.rifai{at}tch.harvard.edu
Received April 26, 2004; revision received July 26, 2004; accepted July 27, 2004.
Background— Metabolic syndrome (MetS) is defined by the Third Report of the Adult Treatment Panel (ATP III) using criteria easily applied by clinicians and researchers. There is no standard pediatric definition.
Methods and Results— We defined pediatric MetS using criteria analogous to ATP III as 
3 of the following: (1) fasting triglycerides 1.1 mmol/L (100 mg/dL); (2) HDL <1.3 mmol/L (50 mg/dL), except in boys aged 15 to 19 years, in whom the cutpoint was <1.2 mmol/L (45 mg/dL); (3) fasting glucose 6.1 mmol/L (110 mg/dL); (4) waist circumference >75th percentile for age and gender; and (5) systolic blood pressure >90th percentile for gender, age, and height. MetS prevalence in US adolescents was estimated with the Third National Health and Nutritional Survey 1988 to 1994. Among 1960 children aged 12 years who fasted 8 hours, two thirds had at least 1 metabolic abnormality, and nearly 1 in 10 had MetS. The racial/ethnic distribution was similar to adults: Mexican-Americans, followed by non-Hispanic whites, had a greater prevalence of MetS compared with non-Hispanic blacks (12.9%, [95% CI 10.4% to 15.4%]; 10.9%, [95% CI 8.4% to 13.4%]; and 2.5%, [95% CI 1.3% to 3.7%], respectively). Nearly one third (31.2% [95% CI 28.3% to 34.1%]) of overweight/obese adolescents had MetS.
Conclusions— Our definition of pediatric MetS, designed to be closely analogous to ATP III, found MetS is common in adolescents and has a similar racial/ethnic distribution to adults in this representative national sample. Because childhood MetS likely tracks into adulthood, early identification may help target interventions to improve future cardiovascular health.
Key Words: metabolic syndrome • pediatrics • risk factors
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