Circulation. 2004;110:1847-1854
Published online before print September 20, 2004, doi: 10.1161/01.CIR.0000142616.07367.66
Published online before print September 20, 2004, doi: 10.1161/01.CIR.0000142616.07367.66
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(Circulation. 2004;110:1847-1854.)
© 2004 American Heart Association, Inc.
Stroke |
Functional Recovery of Stroke Rats Induced by Granulocyte Colony-Stimulating Factor–Stimulated Stem Cells
From the Department of Neurology, Neuro-Medical Scientific Center, Tzu-Chi Buddhist General Hospital, Tzu-Chi University, Hualien (W.-C.S., S.-Z.L., H.-I.Y., C.-Y.P., P.-S.Y.); Institute of Molecular Biology, Academia Sinica, Taipei (Y.-S.T., H.L.); and Institutes of Biochemistry, National Yang-Ming University, Taipei (H.L.), Taiwan.
Correspondence to Hung Li, PhD, Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan. E-mail hungli{at}ccvax.sinica.edu.tw
Received October 24, 2003; de novo received January 27, 2004; revision received April 29, 2004; accepted May 3, 2004.
Background— Stroke is a leading cause of death and disability worldwide; however, no effective treatment currently exists.
Methods and Results— Rats receiving subcutaneous granulocyte colony-stimulating factor (G-CSF) showed less cerebral infarction, as evaluated by MRI, and improved motor performance after right middle cerebral artery ligation than vehicle-treated control rats. Subcutaneous administration of G-CSF enhanced the availability of circulating hematopoietic stem cells to the brain and their capacity for neurogenesis and angiogenesis in rats with cerebral ischemia.
Conclusions— G-CSF induced increases in bone marrow cell mobilization and targeting to the brain, reducing the volume of cerebral infarction and improving neural plasticity and vascularization.
Key Words: granulocyte colony-stimulating factor • neuronal plasticity • stem cells, hematopoietic • stroke
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