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(Circulation. 1955;11:447.)
© 1955 American Heart Association, Inc.

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Cardiac Output and Central Volume as Determined by Dye Dilution Curves

Resting Values in Normal Subjects and Patients With Cardiovascular Disease

ALBERT A. KATTUS M.D.¹; ARTHUR U. RIVIN M.D.¹; AARON COHEN M.D.¹; GILBERT S. SOFIO M.D.¹

¹ From the Department of Medicine, University of California Medical Center and the Veterans Administration Center, Los Angeles, California.

Dye dilution curves determined by the method of Hamilton have been obtained from a series of normal subjects and from a group of patients with various types of cardiovascular disorders. Cardiac indices calculated from these curves revealed expected values. Central volume, believed to be an index of pulmonary blood volume, was calculated from the slopes of the down strokes of the curves. Central volume indices in normal subjects averaged 0.590 liters. Central volume in patients with heart disease was frequently normal or less than normal. Only cor pulmonale patients with high output had central volumes significantly greater than normal.