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(Circulation. 2004;109:887-892.)
© 2004 American Heart Association, Inc.

Clinical Investigation and Reports

Coronary Bypass Surgery Performed off Pump Does Not Result in Lower In-Hospital Morbidity Than Coronary Artery Bypass Grafting Performed on Pump

Jean-Francois Légaré, MD; Karen J. Buth, MSc; Sharon King, RN; Jeremy Wood, MD; John A. Sullivan, MD; Camille Hancock Friesen, MD; John Lee, MD; Kier Stewart, MD; Gregory M. Hirsch, MD

From the Division of Cardiovascular Surgery, Dalhousie University, Halifax, Nova Scotia, Canada.

Correspondence to Dr Jean-Francois Légaré, 1796 Summer St, Room 2006, Division of Cardiovascular Surgery, New Halifax Infirmary, Halifax, Nova Scotia, B3H 3A7, Canada. E-mail jean.legare{at}cdha.nshealth.ca

Received September 25, 2003; accepted November 10, 2003.

Background— There is increasing evidence that cardiopulmonary bypass (CPB) may be responsible for the morbidity associated with coronary artery bypass grafting (CABG) surgery. Recent developments in cardiac stabilization devices have made CABG without CPB feasible. However, there is conflicting evidence to date from published trials comparing outcomes between CABG performed with and without CPB, with some trials indicating an advantage to the avoidance of CPB and others showing little benefit.

Methods and Results— In a single-center randomized trial, 300 patients requiring CABG surgery at a single institution were prospectively randomized to have the procedure performed with CPB (n=150) or on the beating heart (n=150). Exclusion criteria for the trial included emergency procedure, concomitant major cardiac procedures, ejection fraction <30%, and reoperation. In-hospital outcomes were analyzed on an intention-to-treat basis. A mean of 3.0±0.9 grafts were performed in the CPB group compared with 2.8±0.9 grafts in the beating-heart group (P=0.06). There were no significant differences between the CPB group and the beating-heart group in mortality (0.7% versus 1.3%; P=1.0), transfusion (8.7% versus 9.3%), perioperative myocardial infarction (0.7% versus 2.7%; P=0.37), permanent stroke (0% versus 1.3%; P=0.50), new atrial fibrillation (32% versus 25%; P=0.20), and deep sternal wound infection (0.7% versus 0%; P=1.0). The mean time to extubation was 4 hours, the mean stay in the intensive care unit was 22 hours, and the median length of hospitalization was 5 days in both groups (P=NS).

Conclusions— In contrast to published trials, we were unable to demonstrate any advantage with CABG performed without CPB in terms of patient morbidity. Excellent results can be obtained with either surgical approach.

Key Words: coronary disease • revascularization • cardiopulmonary bypass

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