(Circulation. 2004;109:2705-2711.)
© 2004 American Heart Association, Inc.
Review: Current Perspective |
From the Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill (K.H., M.L.D., K.L., L.V.H., A.R.D., P.G.); and the Department of Nutrition, Harvard School of Public Health, Boston, Mass (Y.S.).
Correspondence to Dr Ka He, Department of Preventive Medicine, The Feinberg School of Medicine, Northwestern University, 680 North Lake Shore Drive, Suite 1102, Chicago, IL 60611. E-mail kahe{at}northwestern.edu
Background Results from observational studies on fish consumption and coronary heart disease (CHD) mortality are inconsistent.
Methods and Results A meta-analysis of cohort studies was conducted to examine the association between fish intake and CHD mortality. Studies were included if they provided a relative risk (RR) and corresponding 95% CI for CHD mortality in relation to fish consumption and the frequency of fish intake. A database was developed on the basis of 11 eligible studies and 13 cohorts, including 222 364 individuals with an average 11.8 years of follow-up. Pooled RR and 95% CI for CHD mortality were calculated by using both fixed-effect and random-effect models. A linear regression analysis of the log RR weighted by the inverse of variance was performed to assess the possible dose-response relation. Compared with those who never consumed fish or ate fish less than once per month, individuals with a higher intake of fish had lower CHD mortality. The pooled multivariate RRs for CHD mortality were 0.89 (95% CI, 0.79 to 1.01) for fish intake 1 to 3 times per month, 0.85 (95% CI, 0.76 to 0.96) for once per week, 0.77 (95% CI, 0.66 to 0.89) for 2 to 4 times per week, and 0.62 (95% CI, 0.46 to 0.82) for 5 or more times per week. Each 20-g/d increase in fish intake was related to a 7% lower risk of CHD mortality (P for trend=0.03).
Conclusions These results indicate that fish consumption is inversely associated with fatal CHD. Mortality from CHD may be reduced by eating fish once per week or more. (Circulation. 2004;109:2705-2711.)
Key Words: diet coronary heart disease mortality meta-analysis
This article has been cited by other articles:
![]() |
S. S. Bassuk and J. E. Manson Lifestyle and Risk of Cardiovascular Disease and Type 2 Diabetes in Women: A Review of the Epidemiologic Evidence American Journal of Lifestyle Medicine, June 1, 2008; 2(3): 191 - 213. [Abstract] [PDF] |
||||
![]() |
M. Svensson, E. B. Schmidt, K. A. Jorgensen, and J. H. Christensen The effect of n-3 fatty acids on lipids and lipoproteins in patients treated with chronic haemodialysis: a randomized placebo-controlled intervention study Nephrol. Dial. Transplant., April 24, 2008; (2008) gfn180v1. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. L. Hall, K. A. Sanders, T. A. B. Sanders, and P. J. Chowienczyk A High-Fat Meal Enriched with Eicosapentaenoic Acid Reduces Postprandial Arterial Stiffness Measured by Digital Volume Pulse Analysis in Healthy Men J. Nutr., February 1, 2008; 138(2): 287 - 291. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. London, C. Albert, M. E. Anderson, W. R. Giles, D. R. Van Wagoner, E. Balk, G. E. Billman, M. Chung, W. Lands, A. Leaf, et al. Omega-3 Fatty Acids and Cardiac Arrhythmias: Prior Studies and Recommendations for Future Research: A Report from the National Heart, Lung, and Blood Institute and Office of Dietary Supplements Omega-3 Fatty Acids and Their Role in Cardiac Arrhythmogenesis Workshop Circulation, September 4, 2007; 116(10): e320 - e335. [Full Text] [PDF] |
||||
![]() |
C. Chrysohoou, D. B Panagiotakos, C. Pitsavos, J. Skoumas, X. Krinos, Y. Chloptsios, V. Nikolaou, and C. Stefanadis Long-term fish consumption is associated with protection against arrhythmia in healthy persons in a Mediterranean region--the ATTICA study Am. J. Clinical Nutrition, May 1, 2007; 85(5): 1385 - 1391. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. A Beydoun, J. S Kaufman, J. A Satia, W. Rosamond, and A. R Folsom Plasma n-3 fatty acids and the risk of cognitive decline in older adults: the Atherosclerosis Risk in Communities Study Am. J. Clinical Nutrition, April 1, 2007; 85(4): 1103 - 1111. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. M. van Gelder, M. Tijhuis, S. Kalmijn, and D. Kromhout Fish consumption, n-3 fatty acids, and subsequent 5-y cognitive decline in elderly men: the Zutphen Elderly Study Am. J. Clinical Nutrition, April 1, 2007; 85(4): 1142 - 1147. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Wang, W. S Harris, M. Chung, A. H Lichtenstein, E. M Balk, B. Kupelnick, H. S Jordan, and J. Lau n-3 Fatty acids from fish or fish-oil supplements, but not {alpha}-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review Am. J. Clinical Nutrition, July 1, 2006; 84(1): 5 - 17. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Svensson, E. B. Schmidt, K. A. Jorgensen, J. H. Christensen, and on behalf of the OPACH Study Group N-3 Fatty Acids as Secondary Prevention against Cardiovascular Events in Patients Who Undergo Chronic Hemodialysis: A Randomized, Placebo-Controlled Intervention Trial Clin. J. Am. Soc. Nephrol., July 1, 2006; 1(4): 780 - 786. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. L Breslow n-3 Fatty acids and cardiovascular disease Am. J. Clinical Nutrition, June 1, 2006; 83(6): S1477 - 1482S. [Abstract] [Full Text] [PDF] |
||||
![]() |
Authors/Task Force Members, K. Fox, M. A. A. Garcia, D. Ardissino, P. Buszman, P. G. Camici, F. Crea, C. Daly, G. De Backer, P. Hjemdahl, et al. Guidelines on the management of stable angina pectoris: executive summary: The Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology Eur. Heart J., June 1, 2006; 27(11): 1341 - 1381. [Full Text] [PDF] |
||||
![]() |
J. M Geleijnse, I. A Brouwer, and E. J M Feskens Risks and benefits of omega 3 fats: health benefits of omega 3 fats are in doubt. BMJ, April 15, 2006; 332(7546): 915 - 915. [Full Text] |
||||
![]() |
K. He and Y. Song Risks and benefits of omega 3 fats: a few thoughts on systematic review. BMJ, April 15, 2006; 332(7546): 915 - 915. [Full Text] |
||||
![]() |
American Heart Association, S. S. Gidding, B. A. Dennison, L. L. Birch, S. R. Daniels, M. W. Gilman, A. H. Lichtenstein, K. T. Rattay, J. Steinberger, N. Stettler, et al. Dietary Recommendations for Children and Adolescents: A Guide for Practitioners Pediatrics, February 1, 2006; 117(2): 544 - 559. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. M. Albert, K. Oh, W. Whang, J. E. Manson, C. U. Chae, M. J. Stampfer, W. C. Willett, and F. B. Hu Dietary {alpha}-Linolenic Acid Intake and Risk of Sudden Cardiac Death and Coronary Heart Disease Circulation, November 22, 2005; 112(21): 3232 - 3238. [Abstract] [Full Text] [PDF] |
||||
![]() |
Endorsed by the American Academy of Pediatrics, S. S. Gidding, B. A. Dennison, L. L. Birch, S. R. Daniels, M. W. Gilman, A. H. Lichtenstein, K. T. Rattay, J. Steinberger, N. Stettler, et al. Dietary Recommendations for Children and Adolescents: A Guide for Practitioners: Consensus Statement From the American Heart Association Circulation, September 27, 2005; 112(13): 2061 - 2075. [Abstract] [Full Text] [PDF] |
||||
![]() |
J.A. Iestra, D. Kromhout, Y.T. van der Schouw, D.E. Grobbee, H.C. Boshuizen, and W.A. van Staveren Effect Size Estimates of Lifestyle and Dietary Changes on All-Cause Mortality in Coronary Artery Disease Patients: A Systematic Review Circulation, August 9, 2005; 112(6): 924 - 934. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. B Hu Protein, body weight, and cardiovascular health Am. J. Clinical Nutrition, July 1, 2005; 82(1): 242S - 247S. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Abuissa, J. H. O'Keefe Jr, W. Harris, and C. J. Lavie Autonomic Function, Omega-3, and Cardiovascular Risk Chest, April 1, 2005; 127(4): 1088 - 1091. [Full Text] [PDF] |
||||
![]() |
R. Lehman Evidently... Evid. Based Med., November 1, 2004; 9(6): 167 - 167. [Full Text] [PDF] |
||||
![]() |
Other articles noted Evid. Based Med., November 1, 2004; 9(6): 191 - 192. [Full Text] [PDF] |
||||
![]() |
K. D. Monahan, T. E. Wilson, and C. A. Ray Omega-3 Fatty Acid Supplementation Augments Sympathetic Nerve Activity Responses to Physiological Stressors in Humans Hypertension, November 1, 2004; 44(5): 732 - 738. [Abstract] [Full Text] [PDF] |
||||
![]() |
BMJ, July 3, 2004; 329(7456): 60 - 60. [Full Text] [PDF] |
||||
|
Circulation Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search Copyright © 2004 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited. |