This Article Full Text Full Text (PDF) All Versions of this Article: 109/20/2398    most recent 01.CIR.0000129232.61483.43v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kawai, Y. Articles by Yasuda, T. Search for Related Content PubMed PubMed Citation Articles by Kawai, Y. Articles by Yasuda, T. Pubmed/NCBI databases Substance via MeSH Medline Plus Health Information Heart Attack Related Collections Other diagnostic testing

(Circulation. 2004;109:2398-2400.)
© 2004 American Heart Association, Inc.

Brief Rapid Communications

Diagnostic Use of Serum Deoxyribonuclease I Activity as a Novel Early-Phase Marker in Acute Myocardial Infarction

Yasuyuki Kawai, MD; Masahiro Yoshida, MD; Kenichiro Arakawa, MD; Teruhiko Kumamoto, MD; Norihiro Morikawa, MD; Katsuhiko Masamura, MD; Hiroshi Tada, MD; Sachiko Ito, MD; Hiroshi Hoshizaki, MD; Shigeru Oshima, MD; Koichi Taniguchi, MD; Hidekazu Terasawa, MD; Isamu Miyamori, MD; Koichiro Kishi, MD; Toshihiro Yasuda, PhD

From the Third Department of Internal Medicine (Y.K., M.Y., K.A., T.K., N.M., K.M., I.M.), Department of Emergency Medicine (H.T.), and Department of Biology (T.Y.), Faculty of Medical Sciences, University of Fukui, Fukui; Division of Cardiology (H.T., S.I., H.H., S.O., K.T.), Gunma Prefecture Cardiovascular Center, Gunma; and Department of Legal Medicine (K.K.), Gunma University Graduate School of Medicine, Gunma, Japan.

Correspondence to Toshihiro Yasuda, PhD, Department of Biology, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan. E-mail tyasuda{at}fmsrsa.fukui-med.ac.jp

Received November 15, 2003; de novo received February 13, 2004; revision received April 8, 2004; accepted April 9, 2004.

Background— The delayed release of serum cardiac markers such as creatine kinase isoenzyme MB and equivocal early electrocardiographic changes have hampered a diagnosis of acute myocardial infarction (AMI) in the early phase after its onset. Therefore, a reliable serum biochemical marker for the diagnosis of AMI in the very early phase is desirable.

Methods and Results— Serum samples were collected from the patients with AMI, unstable angina pectoris, stable angina pectoris, and other diseases. Levels of serum deoxyribonuclease I (DNase I) activity in the patients were determined. An abrupt elevation of serum DNase I activity was observed within approximately 3 hours of the onset of symptoms in patients with AMI, with significantly higher activity levels (21.7±5.10 U/L) in this group compared with the other groups with unstable angina pectoris (10.4±4.41 U/L), angina pectoris (10.8±3.70 U/L), and other diseases (9.22±4.16 U/L). Levels of the DNase I activity in serum then exhibited a marked time-dependent decline within 12 hours and had returned to basal levels within 24 hours.

Conclusions— We suggest that serum DNase I activity could be used as a new diagnostic marker for the early detection of AMI.

Key Words: myocardial infarction • enzymes • diagnosis

This article has been cited by other articles:

				N. Morikawa, Y. Kawai, K. Arakawa, T. Kumamoto, I. Miyamori, H. Akao, M. Kitayama, K. Kajinami, J.-D. Lee, H. Takeshita, et al. Serum deoxyribonuclease I activity can be used as a novel marker of transient myocardial ischaemia: results in vasospastic angina pectoris induced by provocation test Eur. Heart J., December 2, 2007; 28(24): 2992 - 2997. [Abstract] [Full Text] [PDF]

				E. Giannitsis and H. A. Katus Ability of DNase I activity to detect myocardial ischaemia in vasospastic angina a view through a monocle? Eur. Heart J., December 2, 2007; 28(24): 2955 - 2956. [Full Text] [PDF]

				T. Kumamoto, Y. Kawai, K. Arakawa, N. Morikawa, J. Kuribara, H. Tada, K. Taniguchi, R. Tatami, I. Miyamori, Y. Kominato, et al. Association of Gln222Arg polymorphism in the deoxyribonuclease I (DNase I) gene with myocardial infarction in Japanese patients Eur. Heart J., September 1, 2006; 27(17): 2081 - 2087. [Abstract] [Full Text] [PDF]

				F. Cipollone Deoxyribonuclease I: exploring the hidden side of myocardial infarction Eur. Heart J., September 1, 2006; 27(17): 2031 - 2033. [Full Text] [PDF]

				K. Arakawa, Y. Kawai, T. Kumamoto, N. Morikawa, M. Yoshida, H. Tada, R. Kawaguchi, K. Taniguchi, I. Miyamori, Y. Kominato, et al. Serum deoxyribonuclease I activity can be used as a sensitive marker for detection of transient myocardial ischaemia induced by percutaneous coronary intervention Eur. Heart J., November 2, 2005; 26(22): 2375 - 2380. [Abstract] [Full Text] [PDF]

				E. Giannitsis and H. A. Katus Mirror, mirror on the wall: the quest for the earliest marker of myocardial ischaemia Eur. Heart J., November 2, 2005; 26(22): 2349 - 2350. [Full Text] [PDF]