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(Circulation. 2004;109:207-214.)
© 2004 American Heart Association, Inc.

Clinical Investigation and Reports

Role of Magnetic Resonance Angiography in the Diagnosis of Major Aortopulmonary Collateral Arteries and Partial Anomalous Pulmonary Venous Drainage

Sanjay K. Prasad, BSc, MD, MRCP; Nikolaos Soukias, MD; Timothy Hornung, MD, MRCP; Mohammed Khan, MSc, MPH; Dudley J. Pennell, MD, FRCP, FESC; Michael A. Gatzoulis, MD, PhD, FESC; Raad H. Mohiaddin, MD, MRCP, FRCR, FESC

From the Cardiovascular Magnetic Resonance Unit (S.K.P., D.J.P., R.H.M.) and Adult Congenital Heart Disease Unit (N.K.S., T.H., M.K., M.A.G.), Royal Brompton Hospital, London, UK.

Correspondence to Dr Raad H. Mohiaddin, Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, Sydney St, London, SW3 6NP, United Kingdom. E-mail r.mohiaddin{at}rbh.nthames.nhs.uk

Received June 3, 2003; revision received September 19, 2003; accepted September 30, 2003.

Background— Accurate diagnosis of major aortopulmonary collaterals (MAPCAs) and partial anomalous pulmonary venous drainage (PAPVD) in adult patients with congenital heart disease is important but problematic. Three-dimensional contrast-enhanced magnetic resonance angiography (MRA) provides a minimally invasive technique to allow detailed studies in a single breath-hold.

Methods and Results— We assessed the role of contrast-enhanced 3D MRA in 29 consecutive adult patients with a diagnosis of MAPCAs (n=16) or PAPVD (n=13) made by echocardiogram, cardiac catheterization, or surgical inspection. MRA was performed with a 3D spoiled gradient-echo technique with intravenous gadolinium-DTPA (0.2 mmol/kg). In both types of pathology, there was excellent correlation between MRA and the cardiac catheterization, echocardiogram, or surgical inspection. Additional information was gained for patients with MAPCAs on confluence and size of pulmonary arteries (n=13 had central arteries), pulmonary artery stenosis (n=3), aneurysmal dilatation of pulmonary artery (n=1), and additional anomalous vascular abnormality (n=3). Shunt assessment, where present (9 of 16), showed patency in all cases (100%). For adults with PAPVD, further information was obtained on drainage origin (n=11). There were no complications.

Conclusions— Contrast-enhanced 3D MRA provides a fast, noninvasive, radiation-free method of accurate and comprehensive diagnosis of MAPCAs and PAPVD in adult patients.

Key Words: magnetic resonance imaging • heart defects, congenital • diagnosis

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