Circulation. 2004;109:1580-1589
doi: 10.1161/01.CIR.0000120390.68287.BB
doi: 10.1161/01.CIR.0000120390.68287.BB
(Circulation. 2004;109:1580-1589.)
© 2004 American Heart Association, Inc.
Review: Current Perspective |
Hypertrophy of the Heart
A New Therapeutic Target?
From the Department of Cardiology (Innere Medizin III), University of Heidelberg (N.F., H.A.K.), Heidelberg, Germany, and Departments of Molecular Biology (E.N.O., J.A.H.) and Internal Medicine (J.A.H.) and the Donald W. Reynolds Cardiovascular Clinical Research Center (E.N.O., J.A.H.), University of Texas Southwestern Medical Center, Dallas, Tex.
Correspondence to Joseph A. Hill, MD, PhD, Cardiology Division, Department of Internal Medicine, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-8573. E-mail joseph.hill{at}UTsouthwestern.edu
Recent studies call into question the necessity of hypertrophic growth of the heart as a "compensatory" response to hemodynamic stress. These findings, coupled with recent progress in dissecting the molecular bases of hypertrophy, raise the prospect of suppressing hypertrophy without provoking circulatory insufficiency. In this article, we focus on signaling pathways that hold promise as potential targets for therapeutic intervention. We also summarize observations from animal models and clinical trials that suggest benefit from an antihypertrophic strategy.
Key Words: hypertrophy • heart failure • signal transduction
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 |
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|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 C.-H. Chu, B.-S. Tzang, L.-M. Chen, C.-H. Kuo, Y.-C. Cheng, L.-Y. Chen, F.-J. Tsai, C.-H. Tsai, W.-W. Kuo, and C.-Y. Huang IGF-II/mannose-6-phosphate receptor signaling induced cell hypertrophy and atrial natriuretic peptide/BNP expression via G{alpha}q interaction and protein kinase C-{alpha}/CaMKII activation in H9c2 cardiomyoblast cells J. Endocrinol., May 1, 2008; 197(2): 381 - 390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. P. Alibin, M. A. Kopilas, and H. D. I. Anderson Suppression of Cardiac Myocyte Hypertrophy by Conjugated Linoleic Acid: ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS {alpha} AND {gamma} J. Biol. Chem., April 18, 2008; 283(16): 10707 - 10715. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
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|
|
|
|
 |
|
 N. Degousee, S. Fazel, D. Angoulvant, E. Stefanski, S.-C. Pawelzik, M. Korotkova, S. Arab, P. Liu, T. F. Lindsay, S. Zhuo, et al. Microsomal Prostaglandin E2 Synthase-1 Deletion Leads to Adverse Left Ventricular Remodeling After Myocardial Infarction Circulation, April 1, 2008; 117(13): 1701 - 1710. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 L. Chen, J. Zhang, T. X. Gan, Y. Chen-Izu, J. D. Hasday, M. Karmazyn, C. W. Balke, and S. M. Scharf Left ventricular dysfunction and associated cellular injury in rats exposed to chronic intermittent hypoxia J Appl Physiol, January 1, 2008; 104(1): 218 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
D. Frank, C. Kuhn, M. van Eickels, D. Gehring, C. Hanselmann, S. Lippl, R. Will, H. A. Katus, and N. Frey Calsarcin-1 Protects Against Angiotensin-II Induced Cardiac Hypertrophy Circulation, November 27, 2007; 116(22): 2587 - 2596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. MacDonnell, H. Kubo, D. M. Harris, X. Chen, R. Berretta, M. F. Barbe, S. Kolwicz, P. O. Reger, A. Eckhart, B. F. Renna, et al. Calcineurin inhibition normalizes beta-adrenergic responsiveness in the spontaneously hypertensive rat Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H3122 - H3129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Loyer, P. Oliviero, T. Damy, E. Robidel, F. Marotte, C. Heymes, and J.-L. Samuel Effects of sex differences on constitutive nitric oxide synthase expression and activity in response to pressure overload in rats Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H2650 - H2658. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. S. Buys, M. J. Raher, S. L. Blake, T. G. Neilan, A. R. Graveline, J. J. Passeri, M. Llano, T. M. Perez-Sanz, F. Ichinose, S. Janssens, et al. Cardiomyocyte-restricted restoration of nitric oxide synthase 3 attenuates left ventricular remodeling after chronic pressure overload Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H620 - H627. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Appert-Collin, S. Cotecchia, M. Nenniger-Tosato, T. Pedrazzini, and D. Diviani The A-kinase anchoring protein (AKAP)-Lbc-signaling complex mediates {alpha}1 adrenergic receptor-induced cardiomyocyte hypertrophy PNAS, June 12, 2007; 104(24): 10140 - 10145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-L. Li, Z.-G. She, T.-B. Li, A.-B. Wang, Q. Yang, Y.-S. Wei, Y.-G. Wang, and D.-P. Liu Overexpression of Myofibrillogenesis Regulator-1 Aggravates Cardiac Hypertrophy Induced by Angiotensin II in Mice Hypertension, June 1, 2007; 49(6): 1399 - 1408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. E. Hannigan, J. G. Coles, and S. Dedhar Integrin-Linked Kinase at the Heart of Cardiac Contractility, Repair, and Disease Circ. Res., May 25, 2007; 100(10): 1408 - 1414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Fisch, S. Gray, S. Heymans, S. M. Haldar, B. Wang, O. Pfister, L. Cui, A. Kumar, Z. Lin, S. Sen-Banerjee, et al. Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy PNAS, April 24, 2007; 104(17): 7074 - 7079. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Schillinger, C. Christians, S. Sossalla, N. Teucher, P. Nguyen Van, H. Kogler, O. Zeitz, and G. Hasenfuss {alpha}1-adrenergic stress induces downregulation of Na+/Ca2+ exchanger in myocardial preparations from rabbits at physiological preload Eur J Heart Fail, April 1, 2007; 9(4): 329 - 335. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Fielitz, S. Philipp, L. R. Herda, E. Schuch, B. Pilz, C. Schubert, V. Gunzler, R. Willenbrock, and V. Regitz-Zagrosek Inhibition of prolyl 4-hydroxylase prevents left ventricular remodelling in rats with thoracic aortic banding Eur J Heart Fail, April 1, 2007; 9(4): 336 - 342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Lemmens, V. F.M. Segers, M. Demolder, M. Michiels, P. Van Cauwelaert, and G. W. De Keulenaer Endogenous inhibitors of hypertrophy in concentric versus eccentric hypertrophy Eur J Heart Fail, April 1, 2007; 9(4): 352 - 356. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. V. Alvarez, D. E. Johnson, D. Sowah, D. Soliman, P. E. Light, Y. Xia, M. Karmazyn, and J. R. Casey Carbonic anhydrase inhibition prevents and reverts cardiomyocyte hypertrophy J. Physiol., February 15, 2007; 579(1): 127 - 145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Dickhout and R. C. Austin Proteasomal Regulation of Cardiac Hypertrophy: Is Demolition Necessary for Building? Circulation, October 24, 2006; 114(17): 1796 - 1798. [Full Text] [PDF]
|
|
|
|
|
|
J. B. Pillai, M. Gupta, S. B. Rajamohan, R. Lang, J. Raman, and M. P. Gupta Poly(ADP-ribose) polymerase-1-deficient mice are protected from angiotensin II-induced cardiac hypertrophy Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1545 - H1553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hannenhalli, M. E. Putt, J. M. Gilmore, J. Wang, M. S. Parmacek, J. A. Epstein, E. E. Morrisey, K. B. Margulies, and T. P. Cappola Transcriptional Genomics Associates FOX Transcription Factors With Human Heart Failure Circulation, September 19, 2006; 114(12): 1269 - 1276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. G. Ni, K. Berenji, N. Wang, M. Oh, N. Sachan, A. Dey, J. Cheng, G. Lu, D. J. Morris, D. H. Castrillon, et al. Foxo Transcription Factors Blunt Cardiac Hypertrophy by Inhibiting Calcineurin Signaling Circulation, September 12, 2006; 114(11): 1159 - 1168. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Srivastava and S. Yu Stretching to meet needs: integrin-linked kinase and the cardiac pump Genes & Dev., September 1, 2006; 20(17): 2327 - 2331. [Full Text] [PDF]
|
|
|
|
 |
|
 G. Liu and F. Daneshgari Temporal diabetes- and diuresis-induced remodeling of the urinary bladder in the rat Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2006; 291(3): R837 - R843. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. London Natriuretic Peptides and Cardiac Hypertrophy J. Am. Coll. Cardiol., August 1, 2006; 48(3): 506 - 507. [Full Text] [PDF]
|
|
|
|
 |
|
 X. Chen, S. P. Shevtsov, E. Hsich, L. Cui, S. Haq, M. Aronovitz, R. Kerkela, J. D. Molkentin, R. Liao, R. N. Salomon, et al. The {beta}-Catenin/T-Cell Factor/Lymphocyte Enhancer Factor Signaling Pathway Is Required for Normal and Stress-Induced Cardiac Hypertrophy Mol. Cell. Biol., June 15, 2006; 26(12): 4462 - 4473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kong, P. Tannous, G. Lu, K. Berenji, B. A. Rothermel, E. N. Olson, and J. A. Hill Suppression of Class I and II Histone Deacetylases Blunts Pressure-Overload Cardiac Hypertrophy Circulation, June 6, 2006; 113(22): 2579 - 2588. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-M. Zhang, J. Bo, G. E. Taffet, J. Chang, J. Shi, A. K. Reddy, L. H. Michael, M. D. Schneider, M. L. Entman, R. J. Schwartz, et al. Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis FASEB J, May 1, 2006; 20(7): 916 - 925. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Perrino and H. A. Rockman GATA4 and the Two Sides of Gene Expression Reprogramming Circ. Res., March 31, 2006; 98(6): 715 - 716. [Full Text] [PDF]
|
|
|
|
|
|
P. M. Okin, R. B. Devereux, E. Gerdts, S. M. Snapinn, K. E. Harris, S. Jern, S. E. Kjeldsen, S. Julius, J. M. Edelman, L. H. Lindholm, et al. Impact of Diabetes Mellitus on Regression of Electrocardiographic Left Ventricular Hypertrophy and the Prediction of Outcome During Antihypertensive Therapy: The Losartan Intervention For Endpoint (LIFE) Reduction in Hypertension Study Circulation, March 28, 2006; 113(12): 1588 - 1596. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Mitchell, A. Ota, W. Foster, B. Zhang, Z. Fang, S. Patel, S. F. Nelson, S. Horvath, and Y. Wang Distinct gene expression profiles in adult mouse heart following targeted MAP kinase activation Physiol Genomics, March 13, 2006; 25(1): 50 - 59. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Zhang, T. Anger, J. Su, J. Hao, X. Xu, M. Zhu, A. Gach, L. Cui, R. Liao, and U. Mende Selective Loss of Fine Tuning of Gq/11 Signaling by RGS2 Protein Exacerbates Cardiomyocyte Hypertrophy J. Biol. Chem., March 3, 2006; 281(9): 5811 - 5820. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Razeghi and H. Taegtmeyer Cardiac Remodeling: UPS Lost in Transit Circ. Res., November 11, 2005; 97(10): 964 - 966. [Full Text] [PDF]
|
|
|
|
|
|
K. R. Sipido and D. Eisner Something old, something new: Changing views on the cellular mechanisms of heart failure Cardiovasc Res, November 1, 2005; 68(2): 167 - 174. [Full Text] [PDF]
|
|
|
|
|
|
G.-L. Wang, G.-X. Wang, S. Yamamoto, L. Ye, H. Baxter, J. R Hume, and D. Duan Molecular mechanisms of regulation of fast-inactivating voltage-dependent transient outward K+ current in mouse heart by cell volume changes J. Physiol., October 15, 2005; 568(2): 423 - 443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Rothermel, K. Berenji, P. Tannous, W. Kutschke, A. Dey, B. Nolan, K.-D. Yoo, E. Demetroulis, M. Gimbel, B. Cabuay, et al. Differential activation of stress-response signaling in load-induced cardiac hypertrophy and failure Physiol Genomics, September 21, 2005; 23(1): 18 - 27. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kupari, H. Turto, and J. Lommi Left ventricular hypertrophy in aortic valve stenosis: preventive or promotive of systolic dysfunction and heart failure? Eur. Heart J., September 1, 2005; 26(17): 1790 - 1796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. P.J. Buermans and W. J. Paulus Iconoclasts topple adaptive myocardial hypertrophy in aortic stenosis Eur. Heart J., September 1, 2005; 26(17): 1697 - 1699. [Full Text] [PDF]
|
|
|
|
|
|
J. Yoshioka, R. N. Prince, H. Huang, S. B. Perkins, F. U. Cruz, C. MacGillivray, D. A. Lauffenburger, and R. T. Lee Cardiomyocyte hypertrophy and degradation of connexin43 through spatially restricted autocrine/paracrine heparin-binding EGF PNAS, July 26, 2005; 102(30): 10622 - 10627. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Berenji, M. H. Drazner, B. A. Rothermel, and J. A. Hill Does load-induced ventricular hypertrophy progress to systolic heart failure? Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H8 - H16. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Secko Straight to the heart with Viagra Can. Med. Assoc. J., April 12, 2005; 172(8): 993 - 993. [Full Text] [PDF]
|
|
|
|
|
|
J. B. Pillai, H. M. Russell, J. Raman, V. Jeevanandam, and M. P. Gupta Increased expression of poly(ADP-ribose) polymerase-1 contributes to caspase-independent myocyte cell death during heart failure Am J Physiol Heart Circ Physiol, February 1, 2005; 288(2): H486 - H496. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Graf and P. Stawowy Osteopontin: A Protective Mediator of Cardiac Fibrosis? Hypertension, December 1, 2004; 44(6): 809 - 810. [Full Text] [PDF]
|
|
|
|
|
|
M. Sano and M. D. Schneider Cyclin-Dependent Kinase-9: An RNAPII Kinase at the Nexus of Cardiac Growth and Death Cascades Circ. Res., October 29, 2004; 95(9): 867 - 876. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Chang, T. A. McKinsey, C. L. Zhang, J. A. Richardson, J. A. Hill, and E. N. Olson Histone Deacetylases 5 and 9 Govern Responsiveness of the Heart to a Subset of Stress Signals and Play Redundant Roles in Heart Development Mol. Cell. Biol., October 1, 2004; 24(19): 8467 - 8476. [Abstract] [Full Text] [PDF]
|
|