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(Circulation. 2003;108:2219.)
© 2003 American Heart Association, Inc.

Clinical Investigation and Reports

Blood Oxygen Level–Dependent Magnetic Resonance Imaging in Patients with Stress-Induced Angina

Matthias G. Friedrich, MD, FESC; Thoralf Niendorf, PhD; Jeanette Schulz-Menger, MD; C. Michael Gross, MD; Rainer Dietz, MD

From Helios-Klinikum Berlin, Franz-Volhard-Klinik, Kardiologie Charité Campus Berlin-Buch, Medizinische Fakultaet der Humboldt-Universitaet Berlin, Germany, and GE Medical Systems (T.N.), Milwaukee, Wisc.

Correspondence to Matthias G. Friedrich, MD, Franz-Volhard-Klinik Helios-Klinikum Berlin Charité Campus Buch, Humboldt-Universitaet Berlin Wiltbergstrasse 50, 13125 Berlin, Germany. E-mail friedrich{at}fvk-berlin.de

Received January 15, 2002; de novo received May 27, 2003; revision received August 4, 2003; accepted August 13, 2003.

Background— Blood oxygen level–dependent (BOLD) MRI reflects tissue oxygenation and may be useful for the detection of myocardial ischemia in patients with suspected coronary artery disease.

Methods and Results— We studied 25 patients with stress-induced angina using a T₂*-sensitive echo planar imaging sequence before and during adenosine in a single-slice approach. BOLD-MRI results were compared with quantitative angiography and adenosine thallium single-photon emission computed tomography (SPECT). Although image quality was variable because of artifacts, no data were excluded from the analysis. During adenosine, a mean signal intensity decrease was observed for myocardial segments related to coronary stenoses >75%. On average, a nonsignificant increase was observed in the other segments. The angiographically determined stenosis was correlated with BOLD-MRI results. Including all segments and using BOLD-MRI signal intensity increase cutoff value of 1.2%, BOLD-MRI had a sensitivity of 88% and a specificity of 47% to correctly classify severe stenoses. Adenosine thallium SPECT data from distal segments of the same coronary territory were also correlated with BOLD-MRI. However, variability was substantial.

Conclusions— In patients with stress-induced angina, adenosine BOLD-MRI detects myocardial ischemia in myocardial segments related to severe coronary stenoses. Its potential will increase with additional improvement of spatial coverage and image quality.

Key Words: magnetic resonance imaging • perfusion • adenosine • coronary heart disease • ischemia

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